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This study aimed to review published case reports and FDA Adverse Event Reporting System (FAERS) spontaneous reports to assess cannabis\u2013drug interactions in persons aged 18 and over. A literature search identified 20 case reports that were each assessed for drug interaction causality using the Drug Interaction Probability Scale. Data collected from the FAERS revealed a greater proportion of reports mentioning serious outcomes, including death, when cannabis was used concomitantly with controlled substances compared to noncontrolled substances. Fisher's exact test showed a statistically significant difference between the controlled and noncontrolled groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.043). Overall, these findings emphasize the need for additional research and vigilant monitoring of cannabis use when combined with other medications.<\/jats:p>","DOI":"10.1002\/prp2.70047","type":"journal-article","created":{"date-parts":[[2024,12,25]],"date-time":"2024-12-25T06:38:49Z","timestamp":1735108729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Part 2: Drug Interactions Involving Cannabis Products in Persons Aged 18 and Over: A Summary of Published Case Reports and Analysis of the <scp>FDA<\/scp> Adverse Event Reporting System"],"prefix":"10.1002","volume":"13","author":[{"given":"Maryann R.","family":"Chapin","sequence":"first","affiliation":[{"name":"Department of Pharmacy &amp; Therapeutics, School of Pharmacy University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra L.","family":"Kane\u2010Gill","sequence":"additional","affiliation":[{"name":"Department of Pharmacy &amp; Therapeutics, School of Pharmacy University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Biomedical Informatics University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy &amp; Therapeutics, School of Pharmacy University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kojo","family":"Abanyie","sequence":"additional","affiliation":[{"name":"Department of Biomedical Informatics University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanya B.","family":"Taneja","sequence":"additional","affiliation":[{"name":"Intelligent Systems Program University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Egbert","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Manitoba  Winnipeg Manitoba Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary F.","family":"Paine","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences Washington State University  Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2993-2085","authenticated-orcid":false,"given":"Richard D.","family":"Boyce","sequence":"additional","affiliation":[{"name":"Department of Pharmacy &amp; Therapeutics, School of Pharmacy University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Department of Biomedical Informatics University of Pittsburgh  Pittsburgh Pennsylvania USA"},{"name":"Intelligent Systems Program University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"\u201cNorth America Legal Cannabis Market Size Report 2030 \u201daccessed December 19 2022 https:\/\/www.grandviewresearch.com\/industry\u2010analysis\/north\u2010america\u2010legal\u2010cannabis\u2010market\u2010report."},{"key":"e_1_2_10_3_1","unstructured":"\u201cGetting Medical Marijuana in Pennsylvania. 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