{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T18:13:03Z","timestamp":1770919983236,"version":"3.50.1"},"reference-count":50,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T00:00:00Z","timestamp":1735171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016179","name":"Hamamatsu Pharma Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016179","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>The lack of effective treatments for dry age\u2010related macular degeneration (AMD) is in part due to a lack of a preclinical animal model that recapitulates features of the clinical state including macular retinal pigment epithelium (RPE) degeneration, also known as geographic atrophy (GA). A nonhuman primate model of GA was developed and its responsiveness to an approved treatment, avacincaptad pegol (ACP), a complement C5 inhibitor, was evaluated. Intravitreal (ivt) administration of sodium iodate (SI) into one eye of male <jats:styled-content style=\"fixed-case\"><jats:italic>Macaca fascicularis<\/jats:italic><\/jats:styled-content> leads to retinal areas (mm<jats:sup>2<\/jats:sup>) of hyper\u2010 or hypo\u2010autofluorescence. Qualitative changes to the retinal structure over time were observed with spectral domain optical coherence tomography (OCT). Six days after SI administration, prior to treatment, mean (\u00b1\u2009SEM) GA of all eyes was 8.2\u2009\u00b1\u20091.8\u2009mm<jats:sup>2<\/jats:sup>. Following randomization to treatment groups, either vehicle or ACP was ivt injected and treatment was continued every 4\u2009weeks, for a total of four treatments. Sixteen weeks after SI administration, the GA area in vehicle\u2010treated eyes was 18.9\u2009\u00b1\u20096.6\u2009mm<jats:sup>2<\/jats:sup>, whereas GA in ACP\u2010treated eyes was 11.4\u2009\u00b1\u20094.0\u2009mm<jats:sup>2<\/jats:sup>, a reduction by about 36%. Increased, followed by decreased, overall macular thickness was observed with OCT over time following SI administration. Treatment with ACP did not change alter macular thickness thinning. Geographic atrophy\u2010like lesions that expand over time are observed following SI administration. The current macaque model could be utilized to further explore the mechanism of dry AMD and to develop more novel therapeutics.<\/jats:p>","DOI":"10.1002\/prp2.70052","type":"journal-article","created":{"date-parts":[[2024,12,26]],"date-time":"2024-12-26T09:01:16Z","timestamp":1735203676000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intravitreal Administration of Avacincaptad Pegol in a Nonhuman Primate Model of Dry Age\u2010Related Macular Degeneration"],"prefix":"10.1002","volume":"13","author":[{"given":"Rintaro","family":"Fujii","sequence":"first","affiliation":[{"name":"Hamamatsu Pharma Research, Inc.  Hamamatsu Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Hamamatsu Pharma Research, Inc.  Hamamatsu Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Itani","sequence":"additional","affiliation":[{"name":"Hamamatsu Pharma Research, Inc.  Hamamatsu Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7372-979X","authenticated-orcid":false,"given":"Aldric","family":"Hama","sequence":"additional","affiliation":[{"name":"Hamamatsu Pharma Research, Inc.  Hamamatsu Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Natsume","sequence":"additional","affiliation":[{"name":"Hamamatsu Pharma Research, Inc.  Hamamatsu Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Hamamatsu Pharma Research, Inc.  Hamamatsu Shizuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214\u2010109X(17)30393\u20105"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01007"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep37279"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2017.08.038"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10081884"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(23)01583\u20100"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(22)00010\u20101"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.612812"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2023.2257604"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000322"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.01.004"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010018\u201025557\u20108"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201052172\u2010y"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.2174\/1566524018666181113104023"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro\u20102023\u20100130"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001283"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2024.02.021"},{"key":"e_1_2_12_19_1","volume-title":"Guide for the Care and Use of Laboratory Animals: Eighth Edition","author":"National Research Council","year":"2011"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2012.10.036"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095\u2010012\u20100721\u20109"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803620-4.00029-3"},{"key":"e_1_2_12_23_1","unstructured":"Iveric \u201cIzervay Package Insert \u201d2023 https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2023\/217225s000lbl.pdf."},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1121"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14748"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222850"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1586\/17469899.2014.939171"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100080"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.22\u20100022"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.10.13.14"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xops.2023.100383"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2147\/EB.S23208"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2021.11.001"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics13243635"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874364101509010036"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2023.109728"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010019\u201011262\u20101"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1448060"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.04\u20101031"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164899"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104419\u20105635\u20104_9"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0603419"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.3791\/56702"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.18\u201024245"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064\u2010010\u20100248\u20106"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16\u201021255"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.21037\/aes\u201021\u201025"},{"key":"e_1_2_12_48_1","first-page":"80","article-title":"Sodium Iodate Causes Photoreceptor Damage in Cynomolgus Monkeys","volume":"57","author":"Liu C.\u2010N.","year":"2016","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1159\/000310074"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41433\u2010023\u201002548\u20102"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.31083\/j.fbs1601003"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.70052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T10:53:26Z","timestamp":1739444006000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.70052"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/prp2.70052"],"URL":"https:\/\/doi.org\/10.1002\/prp2.70052","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,26]]},"assertion":[{"value":"2024-07-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70052"}}