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This scoping review systematically examines evidence on ARI's anticancer effects, mechanisms of action, and translational potential. A systematic search of PubMed, EMBASE, SCOPUS, and Web of Science was conducted following PRISMA\u2010ScR guidelines. Eligible studies included in\u00a0vitro, in\u00a0vivo, and clinical investigations. Data on cancer types, pathways, assays, and outcomes were extracted and synthesized to identify trends and gaps. Of 588 screened studies, 23 met inclusion criteria, spanning cancer types such as breast, colorectal, lung, and brain cancers. ARI modulates key pathways like PI3K\/AKT\/mTOR and Wnt\/\u03b2\u2010catenin, induces apoptosis through mitochondrial dysfunction and ER stress, and overcomes drug resistance by inhibiting P\u2010glycoprotein activity and expression. It exhibits tumor\u2010suppressive effects in\u00a0vivo and synergizes with chemotherapy and radiotherapy. Retrospective population studies suggest ARI's prolactin\u2010sparing properties may reduce the risk of hormone\u2010sensitive cancers such as breast and endometrial cancer compared to antipsychotics with stronger dopamine receptor blockade. Additionally, ARI's ability to target multiple Hallmarks of Cancer highlights its promise as a repurposed anticancer agent. However, current evidence is primarily preclinical and observational, with limited clinical validation. Large\u2010scale cohort studies and prospective trials are essential to confirm its efficacy and address translational challenges. By bridging these gaps, ARI could emerge as a valuable adjunctive therapy in oncology, leveraging its safety profile and versatility to address unmet needs in cancer treatment.<\/jats:p>","DOI":"10.1002\/prp2.70076","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T02:34:06Z","timestamp":1739414046000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["From Psychiatry to Oncology: Exploring the Anti\u2010Neoplastic Mechanisms of Aripiprazole and Its Potential Use in Cancer Treatment"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0938-4720","authenticated-orcid":false,"given":"Liam A.","family":"O'Callaghan","sequence":"first","affiliation":[{"name":"Faculty of Health Sciences and Medicine Bond University  Robina Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4116-4657","authenticated-orcid":false,"given":"Ciara B.","family":"Blum","sequence":"additional","affiliation":[{"name":"School of Medicine and Dentistry Griffith University  Southport Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5950-3038","authenticated-orcid":false,"given":"Katie","family":"Powell","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Medicine Bond University  Robina Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7991-4117","authenticated-orcid":false,"given":"Russ","family":"Chess\u2010Williams","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Medicine Bond University  Robina Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3118-3084","authenticated-orcid":false,"given":"Catherine","family":"McDermott","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences and Medicine Bond University  Robina Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.14"},{"issue":"2","key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrd.2017.17","article-title":"2016 EMA drug approval recommendations","volume":"16","author":"Mullard A.","year":"2017","journal-title":"Nature Reviews. 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