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Here, a series of novel sulfonamide\u2010bearing pyrazolone derivatives (\n                    <jats:bold>1a\u2013f<\/jats:bold>\n                    and\n                    <jats:bold>2a\u2013f<\/jats:bold>\n                    ) were successfully synthesized and characterized by using spectroscopic and analytical methods. The inhibitory activities of these newly synthesized compounds were evaluated both in\u00a0vitro and\n                    <jats:italic>in silico<\/jats:italic>\n                    for their effect on carbonic anhydrases (\n                    <jats:italic>h<\/jats:italic>\n                    CA I and\n                    <jats:italic>h<\/jats:italic>\n                    CA II isoenzymes) and ChEs. The in\u00a0vitro studies showed that these novel compounds demonstrated potential inhibitory activity, with\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>I<\/jats:sub>\n                    values covering the following ranges: 18.03\u2009\u00b1\u20092.86\u201375.54\u2009\u00b1\u20094.91\u2009nM for\n                    <jats:italic>h<\/jats:italic>\n                    CA I, 24.84\u2009\u00b1\u20091.57\u201385.42\u2009\u00b1\u20096.60\u2009nM for\n                    <jats:italic>h<\/jats:italic>\n                    CA II, 7.45\u2009\u00b1\u20090.98\u201316.04\u2009\u00b1\u20091.60\u2009nM for AChE, and 34.78\u2009\u00b1\u20095.88\u2013135.70\u2009\u00b1\u200917.39\u2009nM for BChE. Additionally, many of these compounds showed promising inhibitory activity, and some showed higher potency than reference compounds. While the\n                    <jats:italic>in silico<\/jats:italic>\n                    studies have also identified the potential binding positions of these compounds, using the crystal structures of\n                    <jats:italic>h<\/jats:italic>\n                    CA I, II, AChE and BChE receptors. The varying affinities demonstrated by these designed compounds for ChEs and\n                    <jats:italic>h<\/jats:italic>\n                    CA isoenzymes show that these compounds could hold promise as potential alternative agents for selectively inhibiting ChEs and\n                    <jats:italic>h<\/jats:italic>\n                    CAs in the treatment of diseases such as Alzheimer's disease and glaucoma.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70088","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T19:12:52Z","timestamp":1743016372000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Sulfonamide\u2010Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico\n                    <scp>ADME<\/scp>\n                    \/T Profiling and Molecular Docking Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0578-2761","authenticated-orcid":false,"given":"Nebih","family":"Lolak","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy, Ad\u0131yaman University  Ad\u0131yaman Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suleyman","family":"Akocak","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy, Ad\u0131yaman University  Ad\u0131yaman Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryem","family":"Topal","sequence":"additional","affiliation":[{"name":"Vocational School of Health Services G\u00fcm\u00fc\u015fhane University  G\u00fcm\u00fc\u015fhane Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00dcmit Muhammet","family":"Ko\u00e7yi\u011fit","sequence":"additional","affiliation":[{"name":"Department of Biochemistry 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