{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:24Z","timestamp":1786978344968,"version":"build-2736575974"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["111\u20102320\u2010B\u2010006\u2010035\u2010MY3"],"award-info":[{"award-number":["111\u20102320\u2010B\u2010006\u2010035\u2010MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020950","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["111\u20102320\u2010B\u2010006\u2010020\u2010MY3"],"award-info":[{"award-number":["111\u20102320\u2010B\u2010006\u2010020\u2010MY3"]}],"id":[{"id":"10.13039\/501100020950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Huntington's disease (HD) is a challenging neurodegenerative disorder linked to\n                    <jats:italic>Huntingtin<\/jats:italic>\n                    (\n                    <jats:italic>HTT<\/jats:italic>\n                    ) gene mutation, lacking an effective cure despite numerous therapeutic attempts.\n                    <jats:italic>Cordyceps sinensis<\/jats:italic>\n                    , recognized for its health benefits, particularly its constituent cordycepin, exhibits neuroprotective effects in various neurodegenerative diseases. However, the neuroprotective potential of cordycepin in HD remains insufficiently explored. In this study, in\u00a0vitro experiments using HD cell models demonstrate that cordycepin treatment enhances cell survival, slightly diminishes mutant HTT aggregates, and improves neuronal formation. In\u00a0vivo investigations on R6\/2 HD transgenic mice reveal a modest increase in body weight and a slight amelioration in pathological aggregates following cordycepin administration, although behavioral changes are not significant. While the underlying mechanisms remain unexplored, the findings suggest cordycepin's promise as a supplementary therapeutic for HD, providing neuroprotective effects and reducing mutant protein aggregates.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70091","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T08:07:34Z","timestamp":1744186054000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Exploring Cordycepin as a Neuroprotective Agent in Huntington's Disease: In\u00a0Vitro and In\u00a0Vivo Insights"],"prefix":"10.1002","volume":"13","author":[{"given":"Chih\u2010Wei","family":"Tung","sequence":"first","affiliation":[{"name":"Department of Physiology College of Medicine, National Cheng Kung University  Tainan Taiwan"},{"name":"Institute of Basic Medical Sciences College of Medicine, National Cheng Kung University  Tainan 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