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Chronic treatment with CAR\u2010NMs significantly improved central hemodynamic parameters (systolic and diastolic blood pressure (BP) and its variability) to a similar extent as LOS, and with superior efficacy than CAR\u2010LCF. Although LOS was more effective than CAR\u2010NMs and CAR\u2010LCF in reducing peripheral systolic BP, both LOS and CAR\u2010NMs, in contrast to CAR\u2010LCF, were able to significantly reduce short\u2010term BP variability indexes. Both CAR formulations and LOS significantly reduced aortic media wall thickness and interstitial collagen deposition, and lowered TNF\u2010\u03b1 expression in left ventricle (LV) in SH rats. Only CAR\u2010NMs significantly reduced IL\u20106 expression and were more effective in reducing ventricular TGF\u2010\u03b2 expression in LV of SH rats. These findings suggest that encapsulation of CAR in NMs improved its ability to control central hemodynamics in SH rats when compared with CAR\u2010LCF, mainly due to a greater effect on carotid systolic BP and short\u2010term BP variability, resulting in a higher protection against TOD compared to CAR\u2010LCF.<\/jats:p>","DOI":"10.1002\/prp2.70125","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T10:59:23Z","timestamp":1748861963000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Encapsulation of Carvedilol in Nanomicelles Improves Central Hemodynamics and Target Organ Damage Protection in Spontaneously Hypertensive Rats"],"prefix":"10.1002","volume":"13","author":[{"given":"Luciano","family":"Parola","sequence":"first","affiliation":[{"name":"Departamento de Farmacolog\u00eda, Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"Instituto de Tecnolog\u00eda Farmac\u00e9utica y Biofarmacia (InTecFyB), Facultad de Farmacia y Bioqu\u00edmica Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Denise","family":"Prince","sequence":"additional","affiliation":[{"name":"Instituto Alberto C. 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