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It has been reported that some patients experience abnormal cholesterol levels following treatment, leading to recommendations for the coadministration of lipid\u2010lowering drugs such as statins. In this study, we investigated the potential drug\u2013drug interactions between tofacitinib and the statins simvastatin and lovastatin. In the in\u00a0vitro experiments, rat liver microsomes were employed to evaluate the inhibitory effects of lipid\u2010lowering agents on the metabolism of tofacitinib, with the primary metabolite M8 analyzed using ultra\u2010performance liquid chromatography\u2013tandem mass spectrometry. The results showed that simvastatin and lovastatin significantly inhibited the metabolism of tofacitinib, with IC<jats:sub>50<\/jats:sub> values of 5.837 and 10.68\u2009\u03bcM, respectively. For the in\u00a0vivo pharmacokinetic studies, Sprague\u2013Dawley rats were pretreated with simvastatin or lovastatin via oral gavage for 7\u2009days before the oral gavage of tofacitinib. This pretreatment led to an increased area under the concentration\u2013time curve of tofacitinib, suggesting that a potential reduction in the first metabolism and\/or systemic clearance takes place. These findings demonstrate significant interactions between tofacitinib and certain lipid\u2010lowering agents in the rat model, particularly simvastatin and lovastatin, both in\u00a0vitro and in\u00a0vivo.<\/jats:p>","DOI":"10.1002\/prp2.70127","type":"journal-article","created":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T04:45:52Z","timestamp":1748666752000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessments of <scp>CYP<\/scp>\u2010Inhibition\u2010Based Drug\u2013Drug Interactions Between Tofacitinib and Lipid\u2010Lowering Agents in Rats Both In\u00a0Vitro and In\u00a0Vivo"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8316-6572","authenticated-orcid":false,"given":"Hang","family":"Yang","sequence":"first","affiliation":[{"name":"Peking University Fifth School of Clinical Medicine, The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Institute 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