{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T15:59:22Z","timestamp":1793721562490,"version":"4.6.1"},"reference-count":226,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Alzheimer's disease (AD) is a complex and multifactorial neurodegenerative disorder, recognized as the most prevalent form of dementia. It is characterized by multiple pathological processes, including amyloid\u2010beta accumulation, neurofibrillary tangles, and neuroinflammation. The therapeutic efficacy of traditional single\u2010target drugs has been limited, failing to cure, halt, or reverse disease progression. Therefore, this complex disease warrants comprehensive therapeutic strategies like multi\u2010target drug design (MTDD). MTDD represents a promising strategy to target multiple pathological pathways concurrently. The integration of advanced technologies, including artificial intelligence, machine learning, and nanomedicine, can further enhance the precision and effectiveness of MTDD. This review explores various MTDD approaches, including multi\u2010target\u2010directed ligands, multi\u2010target compound combinations, and polypharmacology. These strategies aim to address the multifaceted nature of AD pathology more effectively than single\u2010target approaches. MTDD offers key advantages, including pathway\u2010level synergy, broader therapeutic scope, and potential for improved efficacy. However, MTDD faces various challenges and limitations, such as the complexity of drug design, difficulty of crossing the blood\u2013brain barrier, and regulatory hurdles. Despite these challenges, recent advancements in computational methods and drug delivery systems show promise in overcoming these barriers. Future research should focus on optimizing delivery systems, improving in silico modeling, and translating multi\u2010target strategies into clinically viable therapies for AD. This review addresses these needs by critically analyzing recent technologies, advantages, challenges, limitations, and future directions of MTDD, underscoring its potential to transform AD treatment.<\/jats:p>","DOI":"10.1002\/prp2.70131","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T11:05:01Z","timestamp":1750244701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["Multi\u2010Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1337-8843","authenticated-orcid":false,"given":"Md Saad","family":"Hossain","sequence":"first","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology East West University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1792-3843","authenticated-orcid":false,"given":"Md Hamed","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Genetic Engineering and Biotechnology East West University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,18]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392\u2010023\u201001484\u20107"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914\u2010023\u201000847\u2010x"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12179"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12694"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.6068"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41514\u2010024\u201000136\u20106"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2000.2.2\/asschachter"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ALZ.12871"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00142"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010022\u201001193\u2010z"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.690372"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2017.01.005"},{"key":"e_1_2_14_14_1","volume-title":"Alzheimer's Disease\u2010Related Epigenetic Changes: Novel Therapeutic Targets, Vol. 61","author":"Paniri A.","year":"2024"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010021\u201000765\u2010w"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/IJMS21061989"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567205014666170317113606"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.996030"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/ALZRT269\/TABLES\/3"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12465"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2024.1399121"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159x16666180315141643"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28031388"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13509"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040208\u2010x"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010015\u20109390\u20100"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.05.020"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.BMC.2022.116742"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c02051"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570180819666220314144219"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.126927"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2020.112180"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/FCHEM.2020.00093\/BIBTEX"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010022\u201002779\u20106"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15121560"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10071510"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.102172"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573409915666190301124210"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.3390\/app13084651"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.117996"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201018534\u20101"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.2174\/0109298673264076230921065945"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010020\u201000413\u20104"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010021\u201000921\u2010z"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2022.12.006"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105314"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010019\u20101591\u20105"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1206572"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026623666230811113231"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1039\/d3ra08333k"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2014.05.006"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010024\u201000397\u2010x"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/d2sc03932j"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2014.09.004"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010021\u201000999\u2010y"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010021\u201001249\u20100"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010021\u201002275\u20106"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2016.06.014"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010024\u201047286\u20105"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12283"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(21)00214\u20103"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010021\u201001309\u20106"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010015\u20100297\u20104"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201001925\u2010w"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/BRAIN\/AWAA286"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2022.06.021"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2022.102575"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010020\u20100624\u20108"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(18)30490\u20103"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2016.05.005"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010014\u20109053\u20106"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2022.101619"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12683"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010020\u201000376\u20106"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010022\u201000296\u2010z"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab112"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.06.038"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.06.029"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2018.11.006"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2022.12.003"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.07.222"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2018.07.001"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010020\u201000189\u2010z"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2021.126779"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010022\u201000279\u20100"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010021\u201001146\u2010y"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583\u2010018\u20100067\u20103"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.14043"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276\u2010023\u201001146\u20102"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010020\u201002215\u2010w"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108352"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.648636"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2016.07.005"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2021.07.014"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201005491\u20106"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12050"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.01.047"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2020.01.134"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2022.10.004"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac285"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652048.2020.1756971"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1844054"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010022\u201010133\u2010y"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10050789"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010020\u20100709\u2010x"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000803\u2010w"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15206"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213\u2010021\u201005942\u20104"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awac096"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14112296"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010020\u201002120\u2010z"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00778"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2021.08.012"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2023.2178414"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00394"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.22662.1"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2023.3810"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2022.01.016"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16060880"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1831"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2023.2182530"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737167.2020.1822738"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2020"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.3390\/gels8110715"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1590\/1516\u20104446\u20102019\u20100735"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12136"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.5581"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041\u2010023\u201001063\u20105"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12175"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2021.62"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000927\u2010z"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346\u2010020\u201000754\u2010z"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111721"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12362"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25174005"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010020\u201000662\u2010x"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111829"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12330"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcis.2022.02.124"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12737"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.2174\/1872208316666220302115901"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmgm.2023.108471"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2023.102113"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-443-13205-6.00009-1"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11064\u2010021\u201003415\u2010W"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.4155\/FMC\u20102019\u20100307"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.DRUDIS.2018.05.015"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9917919"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.3390\/LIFE14020233"},{"key":"e_1_2_14_150_1","doi-asserted-by":"crossref","unstructured":"S.Uddin A.Al Mamun T.Kabir G.Ashraf andM. N.Bin\u2010jumah \u201cMulti\u2010Target Drug Candidates for Multifactorial Alzheimer's Disease: AChE and NMDAR as Molecular Targets \u201d2020.","DOI":"10.1007\/s12035-020-02116-9"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1021\/JM200853T"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1111\/CNS.12269"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1073\/PNAS.1410315111\/SUPPL_FILE\/PNAS.201410315SI.PDF"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11091631"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026616666160927151144"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sciaf.2021.e00826"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.52711\/0974\u2010360X.2021.00774"},{"key":"e_1_2_14_158_1","doi-asserted-by":"crossref","unstructured":"C.Albertini M.Naldi S.Petralla et\u00a0al. \u201cPolypharmacology\u2014Cromolyn\u2010Ibuprofen Conjugates for Alzheimer's Disease \u201d2021Published Online.","DOI":"10.3390\/molecules26041112"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.202300461"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14091914"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1021\/ACS.JMEDCHEM.4C00838"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115672050301014240315065235"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2022.2126464"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1021\/ACS.JMEDCHEM.1C00683\/SUPPL_FILE\/JM1C00683_SI_001.PDF"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-04998-9_21"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.04.008"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2024.107152"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2022.2095261"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173065"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.01.008"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.780602"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioadv.2022.212870"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856\u2010024\u201000527\u20106"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000826\u20103"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389450122999210104205732"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13428"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1002\/MED.21764"},{"key":"e_1_2_14_178_1","doi-asserted-by":"crossref","unstructured":"A.Cerveira F.Kremer D.Louren\u00e7o andU. B.Corr\u00eaa \u201cEvaluation Framework for AI\u2010Driven Molecular Design of Multi\u2010Target Drugs: Brain Diseases as a Case Study \u201d2024 IEEE Congr Evol Comput CEC 2024\u2010Proc. 2024;(1) https:\/\/doi.org\/10.1109\/CEC60901.2024.10611839.","DOI":"10.1109\/CEC60901.2024.10611839"},{"key":"e_1_2_14_179_1","doi-asserted-by":"crossref","unstructured":"K. N.Rao B. R.Gandhi M. V.Rao S.Javvadi S. S.Vellela andB. S.Khader \u201cPrediction and Classification of Alzheimer's Disease Using Machine Learning Techniques in 3D MR Images \u201dInt Conf Sustain Comput Smart Syst ICSCSS 2023\u2014Proc.2023 (Icscss) 85\u201390 https:\/\/doi.org\/10.1109\/ICSCSS57650.2023.10169550.","DOI":"10.1109\/ICSCSS57650.2023.10169550"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.834032"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201021330\u20100"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030\u2010024\u201011042\u20100"},{"key":"e_1_2_14_183_1","doi-asserted-by":"crossref","unstructured":"H.Liu X.Lin J.Hu andX.Zhang \u201cA Multi Target Drug Design Method Based on Target Protein Sequence and Feature Similarity.\u201dProc\u20142024 IEEE Int Conf Bioinforma Biomed BIBM 2024. Published Online 2024 pp. 848\u2013851 https:\/\/doi.org\/10.1109\/BIBM62325.2024.10822055.","DOI":"10.1109\/BIBM62325.2024.10822055"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemolab.2023.105049"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2022.2136162"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.3390\/md23020074"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.1002\/BMC.70047"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.5c00172"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae368"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1089\/nat.2014.0480"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1161405"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.2174\/0115680266309968240621072550"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2022.129015"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph17010022"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0211935"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.DRUDIS.2023.103665"},{"key":"e_1_2_14_197_1","unstructured":"A.Myint N.Hlaing andZ. M.Oo \u201cQuantum Computing to Design New More Effective Drugs \u201d20241(February):265\u2013274."},{"key":"e_1_2_14_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.176661"},{"key":"e_1_2_14_199_1","doi-asserted-by":"publisher","DOI":"10.1007\/S11011\u2010023\u201001160\u20103\/METRICS"},{"key":"e_1_2_14_200_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.4c00150"},{"key":"e_1_2_14_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/TRC2.12429"},{"key":"e_1_2_14_202_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2023.2231661"},{"key":"e_1_2_14_203_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40169\u2010017\u20100181\u20102"},{"key":"e_1_2_14_204_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S257494"},{"key":"e_1_2_14_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2023.102941"},{"key":"e_1_2_14_206_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-99-2657-2_13"},{"key":"e_1_2_14_207_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.1c00048"},{"key":"e_1_2_14_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2023.117419"},{"key":"e_1_2_14_209_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9md00441f"},{"key":"e_1_2_14_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scib.2024.03.056"},{"key":"e_1_2_14_211_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020\u2010025\u201001075\u20104"},{"key":"e_1_2_14_212_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21699"},{"key":"e_1_2_14_213_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26061658"},{"key":"e_1_2_14_214_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.02.076"},{"key":"e_1_2_14_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104691"},{"key":"e_1_2_14_216_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00760"},{"key":"e_1_2_14_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2589\u20107500(22)00169\u20108"},{"key":"e_1_2_14_218_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1009302"},{"key":"e_1_2_14_219_1","doi-asserted-by":"publisher","DOI":"10.1080\/17460441.2020.1816962"},{"key":"e_1_2_14_220_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph13110394"},{"key":"e_1_2_14_221_1","doi-asserted-by":"publisher","DOI":"10.4155\/FMC\u20102021\u20100119"},{"key":"e_1_2_14_222_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20107404\u20107_19"},{"key":"e_1_2_14_223_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26010080"},{"key":"e_1_2_14_224_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964\u2010024\u201001607\u20109"},{"key":"e_1_2_14_225_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12450"},{"key":"e_1_2_14_226_1","doi-asserted-by":"publisher","DOI":"10.3389\/FPHAR.2021.730257\/BIBTEX"},{"key":"e_1_2_14_227_1","doi-asserted-by":"publisher","DOI":"10.4155\/FMC.14.97"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.70131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T09:05:35Z","timestamp":1755075935000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.70131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,18]]},"references-count":226,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/prp2.70131"],"URL":"https:\/\/doi.org\/10.1002\/prp2.70131","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,18]]},"assertion":[{"value":"2025-02-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-18","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70131"}}