{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:34Z","timestamp":1786978414181,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T00:00:00Z","timestamp":1749945600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In Peru, 33\u2009113 individuals were diagnosed with tuberculosis (TB) in 2023. While TB treatments are generally effective, 3.4% to 13% of cases are associated with significant adverse drug reactions, with drug\u2010induced liver injury (DILI) being the most prevalent. Limited data exist on genetic risk factors for DILI in Latin America; even less is known about these factors in native Peruvian populations. This study aimed to determine the prevalence of TB drug\u2010metabolizing genotypes in these populations. A cross\u2010sectional analysis was conducted using genetic data from 254 participants from the Peruvian Genome Project (PGP) representing three subpopulations: Coast, Andes, and Amazon. Twenty\u2010three genes associated with TB treatment, include isoniazid, rifampin, ethambutol, and pyrazinamide, as identified in the PharmGKB database, were analyzed. Significant differences were observed in genotype frequencies among subpopulations for\n                    <jats:italic>AGBL4, NAT2, GSTP1, SLCO1B1, NOS<\/jats:italic>\n                    , and\n                    <jats:italic>CYP2B6<\/jats:italic>\n                    genes. The Amazonian population demonstrated a higher risk of DILI due to the increased prevalence of hepatotoxic alleles in\n                    <jats:italic>AGBL4, GSTP1<\/jats:italic>\n                    , and\n                    <jats:italic>SLCO1B1<\/jats:italic>\n                    . In contrast, alleles in the\n                    <jats:italic>NOS<\/jats:italic>\n                    gene indicated a lower risk of hepatotoxicity in the Andean population. However, the high\u2010risk genotypes identified in the study's native Peruvian populations exhibit distinct prevalence patterns compared to those reported in the 1000 Genomes Project. These findings can inform the development of personalized therapeutic strategies to improve TB treatment outcomes among Peru's diverse subpopulations.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70135","type":"journal-article","created":{"date-parts":[[2025,6,15]],"date-time":"2025-06-15T08:23:22Z","timestamp":1749975802000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pharmacogenetic Study of Anti\u2010\n                    <scp>TB<\/scp>\n                    Drugs in the Native Ancestry Peruvian Population"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5093-6067","authenticated-orcid":false,"given":"Luis","family":"Jaramillo\u2010Valverde","sequence":"first","affiliation":[{"name":"INBIOMEDIC, Research and Technological Center  Lima Peru"},{"name":"School of Medicine Universidad Continental  Huancayo 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