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This report presents a comparative study of the pharmacokinetics of ceftazidime and avibactam, utilizing in\u00a0vitro data derived from two experiments with continuous venovenous hemodiafiltration (CVVHDF) simulation and a comparison with a previously published in\u00a0vivo case report. The results highlight the importance of therapeutic drug monitoring and the need for higher dosing or continuous infusion of ceftazidime\u2013avibactam in critically ill children under crontinuous renal replacement therapy (CRRT).<\/jats:p>","DOI":"10.1002\/prp2.70139","type":"journal-article","created":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T05:28:50Z","timestamp":1752816530000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ceftazidime\u2013Avibactam Pharmacokinetic Comparative In\u00a0Vivo\/In Vitro Study in a Critically Ill Children Under High\u2010Volume Continuous Venovenous Hemodiafiltration"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9366-505X","authenticated-orcid":false,"given":"Michael","family":"Thy","sequence":"first","affiliation":[{"name":"Service de M\u00e9decine Intensive et R\u00e9animation Infectieuse H\u00f4pital Bichat Claude\u2010Bernard, AP\u2010HP, Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"UMR 1343, Evaluation Des th\u00e9rapeutiques et Pharmacologie p\u00e9rinatale et p\u00e9diatrique INSERM, Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"UMR 1137, IAME INSERM, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Debs","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation et Surveillance Continue m\u00e9dicochirurgicales H\u00f4pital Necker Enfants\u2010Malades, AP\u2010HP, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabrielle","family":"Lui","sequence":"additional","affiliation":[{"name":"UMR 1343, Evaluation Des th\u00e9rapeutiques et Pharmacologie p\u00e9rinatale et p\u00e9diatrique INSERM, Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Service de Pharmacologie Clinique H\u00f4pital Cochin, AP\u2010HP, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leo","family":"Froelicher\u2010Bournaud","sequence":"additional","affiliation":[{"name":"UMR 1343, Evaluation Des th\u00e9rapeutiques et Pharmacologie p\u00e9rinatale et p\u00e9diatrique INSERM, Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Service de Pharmacologie Clinique H\u00f4pital Cochin, AP\u2010HP, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Marc","family":"Tr\u00e9luyer","sequence":"additional","affiliation":[{"name":"UMR 1343, Evaluation Des th\u00e9rapeutiques et Pharmacologie p\u00e9rinatale et p\u00e9diatrique INSERM, Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Service de Pharmacologie Clinique H\u00f4pital Cochin, AP\u2010HP, Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Unit\u00e9 de Recherche Clinique\u2010Centre D'investigation Clinique, CIC1419 H\u00f4pital Cochin\u2010Necker, AP\u2010HP, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehdi","family":"Oualha","sequence":"additional","affiliation":[{"name":"UMR 1343, Evaluation Des th\u00e9rapeutiques et Pharmacologie p\u00e9rinatale et p\u00e9diatrique INSERM, Universit\u00e9 Paris Cit\u00e9  Paris France"},{"name":"Service de R\u00e9animation et Surveillance Continue m\u00e9dicochirurgicales H\u00f4pital Necker Enfants\u2010Malades, AP\u2010HP, Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2022.01.030"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.11.025"},{"key":"e_1_2_11_4_1","unstructured":"Zavicefta \u201cEuropean Medicines Agency (EMA) \u201dEuropean Medicines Agency accessed January 5 2025 https:\/\/www.ema.europa.eu\/en\/medicines\/human\/EPAR\/zavicefta."},{"key":"e_1_2_11_5_1","unstructured":"FDA \u201cResearch C for DE and. Ceftazidime Avibactam Injection \u201d(2023) https:\/\/www.fda.gov\/drugs\/development\u2010resources\/ceftazidime\u2010avibactam\u2010injection."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.15993"},{"key":"e_1_2_11_7_1","doi-asserted-by":"crossref","unstructured":"M.Thy F.Kecili S.Urien et\u00a0al. \u201cImpact of Pediatric Continuous Renal Replacement Therapy Parameters on Meropenem Piperacillin and Tazobactam Pharmacokinetics: An In\u00a0Vitro Model \u201dExpert Opinion on Drug Metabolism & Toxicology ahead of print December 22 2024 https:\/\/doi.org\/10.1080\/17425255.2024.2443754.","DOI":"10.1080\/17425255.2024.2443754"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2024.2422875"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.70139","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T09:05:54Z","timestamp":1755075954000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.70139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,17]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/prp2.70139"],"URL":"https:\/\/doi.org\/10.1002\/prp2.70139","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"type":"print","value":"2052-1707"},{"type":"electronic","value":"2052-1707"}],"subject":[],"published":{"date-parts":[[2025,7,17]]},"assertion":[{"value":"2025-03-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70139"}}