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We report the first case of a 65\u2010year\u2010old male with Crohn's disease who developed a hemolytic crisis leading to hospitalization shortly after commencement of upadacitinib. An autoimmune condition was excluded but, as his family history was a positive for G6PD deficiency, very low levels of erythrocyte G6PD were detected. Upadacitinib was immediately discontinued with subsequent resolution of hemolysis. This case highlights the importance of rigorous pharmacological surveillance and suggests the need for further studies to clarify the pathogenetic mechanisms underlying this adverse reaction.<\/jats:p>","DOI":"10.1002\/prp2.70143","type":"journal-article","created":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T08:08:35Z","timestamp":1750925315000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Upadacitinib\u2010Induced Hemolysis in a Patient With Glucose\u20106\u2010Phosphate Dehydrogenase Deficiency\u2014A Possible Adverse Drug Reaction"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9044-313X","authenticated-orcid":false,"given":"Laura","family":"Patan\u00e8","sequence":"first","affiliation":[{"name":"IBD\u2010Unit, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"},{"name":"Section of Gastroenterology and Hepatology, PROMISE University of Palermo  Palermo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Costantino","sequence":"additional","affiliation":[{"name":"IBD\u2010Unit, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Muscianisi","sequence":"additional","affiliation":[{"name":"IBD\u2010Unit, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"De Francesco","sequence":"additional","affiliation":[{"name":"IBD\u2010Unit, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Viola","sequence":"additional","affiliation":[{"name":"IBD\u2010Unit, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Fries","sequence":"additional","affiliation":[{"name":"IBD\u2010Unit, Department of Clinical and Experimental Medicine University of Messina  Messina Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ueg2.12317"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2023.108402"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1981.154"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.18943"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.2471\/BLT.23.291224"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13688"},{"key":"e_1_2_9_8_1","unstructured":"\u201cEudravigilance \u201d(2024) https:\/\/dap.ema.europa.eu\/analytics\/saw.dll?PortalPages."},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.0000000000001528"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.1513"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2023.101836"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.70143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T09:06:37Z","timestamp":1755075997000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.70143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6,26]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/prp2.70143"],"URL":"https:\/\/doi.org\/10.1002\/prp2.70143","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6,26]]},"assertion":[{"value":"2025-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70143"}}