{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T02:34:54Z","timestamp":1755225294802,"version":"3.43.0"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T00:00:00Z","timestamp":1751587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Carbapenems, known for their broad\u2010spectrum activity and used as last\u2010line treatment for severe drug\u2010resistant infections, are encountering increasing resistance. Therefore, Thong Nhat Hospital, a national hospital in Vietnam, has implemented the preauthorization of some restricted antibiotics, including carbapenems, to optimize their use on patients. This study aimed to investigate the current use and preauthorization of carbapenems at the hospital. This descriptive cross\u2010sectional study was conducted on the medical records of inpatients having at least one order form for carbapenems from December 2023 to February 2024 at Thong Nhat Hospital. The data regarding microbiological features, carbapenem resistance patterns, characteristics of the use and preauthorization of carbapenems, and treatment outcome were collected for analysis. A total of 348 patients were selected for the study. The median age of patients was 69\u2009years. <jats:styled-content style=\"fixed-case\"><jats:italic>Escherichia coli<\/jats:italic><\/jats:styled-content> was the most frequently isolated Gram\u2010negative bacteria, and <jats:styled-content style=\"fixed-case\"><jats:italic>Acinetobacter baumannii<\/jats:italic><\/jats:styled-content> had the lowest susceptibility to carbapenems. The appropriate rate of carbapenem regimens regarding the hospital guideline was 68.10%. Optimizing dosing was the most common intervention in preauthorization. The rate of patients whose preauthorization process of all restricted antimicrobials complied with the hospital's protocol was 73.28%. Factors associated with lower treatment success included high Charlson score and diagnoses of septic shock, respiratory tract infection, and central nervous system infection. The preauthorization of carbapenems should be enhanced to optimize the appropriate use of carbapenems, particularly in patients with multiple comorbidities and severe infections.<\/jats:p>","DOI":"10.1002\/prp2.70145","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T05:31:28Z","timestamp":1751607088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation on the Use and Preauthorization of Carbapenems at A National Hospital in Vietnam: A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"13","author":[{"given":"Han Ngoc Bao","family":"Pham","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy University of Medicine and Pharmacy  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nhi Truc Y.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nhu Quynh","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Medicine and Pharmacy  Ho Chi Minh City Vietnam"},{"name":"Department of Pharmacy Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"An Thi Thanh","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cam Thi","family":"Le Pham","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nhan Thi Thanh","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hien Thi Thu","family":"Pham","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4151-7861","authenticated-orcid":false,"given":"Thong Duy","family":"Vo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine University of Medicine and Pharmacy  Ho Chi Minh City Vietnam"},{"name":"Department of Gastroenterology University Medical Center Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai Thi Phuong","family":"Tran","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quynh Thi Huong","family":"Bui","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy University of Medicine and Pharmacy  Ho Chi Minh City Vietnam"},{"name":"Department of Pharmacy Thong Nhat Hospital  Ho Chi Minh City Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jacamr\/dlz072"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001462"},{"issue":"1","key":"e_1_2_11_4_1","article-title":"Carbapenem Resistance: A Review","volume":"6","author":"Codjoe F. S.","year":"2017","journal-title":"Medical Sciences (Basel, Switzerland)"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/510393"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw118"},{"key":"e_1_2_11_7_1","unstructured":"World Health Organization \u201cAWaRe Classification of Antibiotics for Evaluation and Monitoring of Use 2023 \u201d 2023 https:\/\/www.who.int\/publications\/i\/item\/WHO\u2010MHP\u2010HPS\u2010EML\u20102023.04."},{"issue":"3","key":"e_1_2_11_8_1","first-page":"370","article-title":"How to Define Obesity? Evidence\u2010Based Multiple Action Points for Public Awareness, Screening, and Treatment: An Extension of Asian\u2010Pacific Recommendations","volume":"17","author":"Pan W. H.","year":"2008","journal-title":"Asia Pacific Journal of Clinical Nutrition"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphys.2016.05.008"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccc.2013.03.016"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ackd.2019.01.004"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.10960917"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2165\/00002018-199615020-00001"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.9.1.23"},{"issue":"1","key":"e_1_2_11_15_1","article-title":"Prevalence of Carbapenem Non\u2010Susceptible Gram\u2010Negative Bacteria at Tertiary Care Hospitals in Saudi Arabia","volume":"15","author":"Aloraifi R. I.","year":"2023","journal-title":"Cureus"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0000000000000125"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jam.15130"},{"key":"e_1_2_11_18_1","article-title":"Carbapenem Antibiotics for Serious Infections","volume":"344","author":"Hawkey P. M.","year":"2012","journal-title":"BMJ (Clinical Research Ed)"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00736-17"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.03.022"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2023.03.019"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.45"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-02950-2"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2009.04.288"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0200067"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-023-07999-2"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.70145","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T09:06:32Z","timestamp":1755075992000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.70145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,4]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/prp2.70145"],"URL":"https:\/\/doi.org\/10.1002\/prp2.70145","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"type":"print","value":"2052-1707"},{"type":"electronic","value":"2052-1707"}],"subject":[],"published":{"date-parts":[[2025,7,4]]},"assertion":[{"value":"2025-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70145"}}