{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:52:00Z","timestamp":1761007920229,"version":"build-2065373602"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp;amp; Perspec"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Spine surgery is performed on 45\u2009000 Australians annually, and opioids are frequently used for pain management before spine surgery, although concerns about their effectiveness and harms persist. Evidence suggests preoperative opioid use is associated with poorer surgical outcomes, yet the prevalence of opioid use before spine surgery in Australia remains unclear. This study aimed to assess the prevalence and predictors of preoperative opioid use among patients undergoing elective spine surgery across geographical settings in NSW, Australia. A multicenter, cross\u2010sectional observational study was conducted with patients scheduled for elective spine surgery at four hospitals representing metropolitan, regional, and rural settings from April 2017 to February 2020. Participants completed a pre\u2010admission questionnaire 2\u20136\u2009weeks before surgery, providing demographic, clinical, and opioid use data. Preoperative opioid use was reported by 50% (33\/66; 95% CI 37%\u201363%) of participants, with minimal variation across metropolitan (49%), regional metropolitan (54%), and regional hospitals (50%). The most frequently used opioids were oxycodone (32%), codeine (20%), and tapentadol (9%). No significant predictors of opioid use were identified in relation to location, sex, socioeconomic status, smoking, or disability, although trends suggested a higher likelihood of opioid use among patients from lower socioeconomic backgrounds. These findings indicate that 50% of patients use opioids before elective spine surgery, with minimal geographical variation. Given the risks of opioids, efforts to better understand and manage opioid use before spine surgery are warranted. Addressing this issue could lead to more effective pain management strategies and improved patient outcomes.<\/jats:p>","DOI":"10.1002\/prp2.70172","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T07:50:24Z","timestamp":1757749824000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Predictors of Opioid Use Before Spine Surgery: A Multicenter, Cross\u2010Sectional Observational Study"],"prefix":"10.1002","volume":"13","author":[{"given":"Shania","family":"Liu","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health, School of Pharmacy The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Stevens","sequence":"additional","affiliation":[{"name":"School of Clinical Medicine St Vincent's Clinical Campus, University of New South Wales  Sydney New South Wales Australia"},{"name":"School of Medicine University of Notre Dame  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5294-3588","authenticated-orcid":false,"given":"Chi","family":"Tran","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, School of Pharmacy The University of Sydney  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashleigh","family":"Collins","sequence":"additional","affiliation":[{"name":"Royal Prince Alfred Hospital  Camperdown New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jed","family":"Duff","sequence":"additional","affiliation":[{"name":"Faculty of Health, School of Nursing Centre for Healthcare Transformation, Queensland University of Technology  Brisbane Queensland Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Rural Clinical School Coffs Harbour Campus, The University of New South Wales  Sydney New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgan","family":"Oddie","sequence":"additional","affiliation":[{"name":"St George Hospital  Kogarah New South Wales Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justine","family":"Naylor","sequence":"additional","affiliation":[{"name":"Whitlam Orthopaedic Research Centre Ingham Institute  Liverpool New South Wales Australia"},{"name":"School of Clinical Medicine UNSW Medicine &amp; 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