{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T15:56:55Z","timestamp":1789660615372,"version":"4.0.1"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T00:00:00Z","timestamp":1759190400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp;amp; Perspec"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>This study aimed to evaluate the safety of colistin therapy by monitoring renal function and electrolyte levels in critically ill neonates with late\u2010onset sepsis (LOS) hospitalized in the neonatal intensive care unit (NICU) between 2015 and 2021. This retrospective case\u2013control study included 58 critically ill neonates treated with colistin for late\u2010onset sepsis and 22 control neonates with late\u2010onset sepsis who did not receive colistin. Data were analyzed to compare patient outcomes, microbiological profiles, and side effects of treatment. Statistical analyses were performed using repeated\u2010measures ANOVA and Bayesian calculations to evaluate serum creatinine levels and biochemical parameters over time. Serum creatinine levels showed similar alterations within the first 7\u2009days of colistin treatment with moderate evidence. However, serum magnesium and sodium levels were lower on the 7th day in the colistin\u2010treated group compared with the control group. Colistin therapy in critically ill neonates with late\u2010onset sepsis appears to be a viable treatment option with an acceptable short\u2010term safety profile. These findings emphasize the importance of routine monitoring of renal function and electrolyte levels during colistin use in neonatal intensive care to minimize potential complications.<\/jats:p>","DOI":"10.1002\/prp2.70178","type":"journal-article","created":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T03:15:43Z","timestamp":1759288543000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety Monitoring of Colistin Therapy in Critically Ill Neonates With Late\u2010Onset Sepsis: A Retrospective Observational Study"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4834-9127","authenticated-orcid":false,"given":"Baran Cengiz","family":"Arcagok","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, School of Medicine Acibadem University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akan","family":"Yaman","sequence":"additional","affiliation":[{"name":"Nisantasi University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turkay","family":"Rzayev","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, School of Medicine Marmara University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nazli","family":"Jalalzada","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, School of Medicine Marmara University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Kandemir","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Istanbul Health and Technology University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asli","family":"Memisoglu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, School of Medicine Marmara University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hulya Selva","family":"Bilgen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Division of Neonatology, School of Medicine Marmara University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,30]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.2807\/ese.13.47.19045-en"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/62.1.39"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S383285"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.898213"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-009-1137-3"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000001655"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0000000000002448"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-318067"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2018.1559817"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-72-6-857"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e3182703790"},{"key":"e_1_2_11_13_1","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s40272-018-0301-5","article-title":"Efficacy and Safety of Intravenous Colistin in Very Low Birth Weight Preterm Infants","volume":"20","author":"Ilhan O.","journal-title":"Paediatric Drugs"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2016.10.002"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.24953\/turkjped.2020.05.011"},{"issue":"4","key":"e_1_2_11_16_1","first-page":"265","article-title":"Asociaci\u00f3n Entre la Concentraci\u00f3n de Vitamina D y la Sepsis Neonatal Extrahospitalaria de Aparici\u00f3n Tard\u00eda [Association Between Vitamin D Level and Community\u2010Acquired Late\u2010Onset Neonatal Sepsis]","volume":"118","author":"Siyah Bilgin B.","year":"2020","journal-title":"Archivos Argentinos de Pediatria"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.24-4-e217"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13312-015-0586-1"}],"container-title":["Pharmacology Research &amp; 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