{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:16:39Z","timestamp":1780640199396,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012547","name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","doi-asserted-by":"publisher","award":["2025GXNSFBA069269"],"award-info":[{"award-number":["2025GXNSFBA069269"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp;amp; Perspec"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Polymyxin B (PMB), a last\u2010resort antibiotic for multidrug\u2010resistant Gram\u2010negative infections, carries significant neurotoxicity risks that remain underrecognized in clinical practice. Here, we present a case of life\u2010threatening diaphragmatic paralysis induced by PMB in a patient with extensive neck and mediastinal infections caused by extensively drug\u2010resistant\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Acinetobacter baumannii<\/jats:italic>\n                    <\/jats:styled-content>\n                    . The patient developed acute respiratory failure due to respiratory paralysis, which resolved completely upon PMB discontinuation. Concurrent use of nephrotoxic agents may have contributed to renal impairment during treatment. This case is helpful in detecting the serious neurotoxic reactions caused by PMB at an early stage; systematic therapeutic drug monitoring combined with real\u2010time renal function assessment aided in the early detection of toxicity, thereby preventing a potentially fatal outcome.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70196","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T10:17:48Z","timestamp":1763374668000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Polymyxin B Induced Acute Diaphragmatic Paralysis: A Case Report Based on Therapeutic Drug Monitoring"],"prefix":"10.1002","volume":"13","author":[{"given":"Yunli","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit, Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaogang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohong","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhai","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit, Guangxi Academy of Medical Sciences The People's Hospital of Guangxi Zhuang Autonomous Region  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.04.189"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196204122661505"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/cc3995"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14740338.2024.2348610"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2015-210787"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-57-2-214"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-1483"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/2324709616638362"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.963140"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/2110-5820-1-14"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105328"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2020.12.009"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)32591-3"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.70196","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T16:56:17Z","timestamp":1765817777000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.70196"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/prp2.70196"],"URL":"https:\/\/doi.org\/10.1002\/prp2.70196","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,17]]},"assertion":[{"value":"2025-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70196"}}