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The 5\u2010HT\n                    <jats:sub>1B<\/jats:sub>\n                    and 5\u2010HT\n                    <jats:sub>1D<\/jats:sub>\n                    Rs are the putative therapeutic targets for \u201ctriptan\u201d\u2010type migraine drugs, and the 5\u2010HT\n                    <jats:sub>1B<\/jats:sub>\n                    R is associated with prosocial effects, relative to autism treatment, consistent with its high expression in limbic and cortical brain regions. Under study is a recently developed drug candidate for autism, (\n                    <jats:italic>S<\/jats:italic>\n                    )\u20105\u2010(2\u2032\u2010fluorophenyl)\u20102\u2010dimethylaminotetralin (FPT), that is a full efficacy pan\u20105\u2010HT\n                    <jats:sub>1<\/jats:sub>\n                    R agonist (pEC50\u2009=\u20097.4, 9.4, and 8.6 at 5\u2010HT1\n                    <jats:sub>A<\/jats:sub>\n                    , 5\u2010HT1\n                    <jats:sub>B<\/jats:sub>\n                    , and 5\u2010HT1\n                    <jats:sub>D<\/jats:sub>\n                    Rs, respectively). FPT demonstrates anti\u2010seizure, anxiolytic, and prosocial properties, as well as reduces stereotypic movements in\n                    <jats:italic>Fmr1<\/jats:italic>\n                    knockout mice, a model for autism. The goal of this study was to compare brain activation patterns of the pan\u20105\u2010HT\n                    <jats:sub>1<\/jats:sub>\n                    R agonist FPT to NLX\u2010112, a highly selective 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    R full agonist (pEC\n                    <jats:sub>50<\/jats:sub>\n                    \u2009=\u20097.5) which also prevents seizures in\n                    <jats:italic>Fmr1<\/jats:italic>\n                    knockout mice, to help establish therapeutic mechanisms in autism. We used pharmacological magnetic resonance imaging (phMRI) in awake C57BL\/J6 mice to assess activation of integrated neuronal circuits as measured by blood oxygen level dependent volume of activation changes, comparing dose\u2010related effects of FPT and NLX\u2010112. The selective 5HT\n                    <jats:sub>1A<\/jats:sub>\n                    R agonist NLX\u2010112 broadly inhibited brain activity in a dose\u2010dependent manner. In contrast, FPT increased global brain activity; however, dose\u2010related effects were complex, suggesting FPT's polypharmacology at 5\u2010HT\n                    <jats:sub>1<\/jats:sub>\n                    Rs and perhaps other receptors are involved in its brain activation pattern.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70199","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T05:09:33Z","timestamp":1777007373000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacologic\n                    <scp>MRI<\/scp>\n                    Brain Imaging Studies of Serotonin 5\u2010\n                    <scp>\n                      HT\n                      <sub>1<\/sub>\n                    <\/scp>\n                    Receptor Agonists in Awake Mice"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-0395-8500","authenticated-orcid":false,"given":"Brittany M.","family":"Brems","sequence":"first","affiliation":[{"name":"Center for Drug Discovery Northeastern University  Boston Massachusetts USA"},{"name":"Department of Pharmaceutical Sciences Northeastern University  Boston Massachusetts USA"},{"name":"Department of Chemistry and Chemical Biology Northeastern University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2745-3653","authenticated-orcid":false,"given":"Erin E.","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Center for Drug Discovery Northeastern University  Boston Massachusetts USA"},{"name":"Department of Pharmaceutical Sciences Northeastern University  Boston Massachusetts USA"},{"name":"Department of Chemistry and Chemical Biology Northeastern University  Boston Massachusetts 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