{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T19:26:51Z","timestamp":1792178811179,"version":"4.4.0"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R56MH11264"],"award-info":[{"award-number":["R56MH11264"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp;amp; Perspec"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    A duplication\/triplication copy number variant in the 9p24.1 chromosomal region with the additional gene copies being located on a small supernumerary marker chromosome has been identified in patients with psychosis. Mice genetically engineered to harbor 9p24.1 duplications or triplications have been shown to display schizophrenia\u2010like phenotypes, including deficits in startle habituation, latent inhibition, working memory, and social interaction and a reduction in the dendritic spine density. Genetic fine\u2010mapping traced these phenotypes to a duplication or triplication of the\n                    <jats:italic>Gldc<\/jats:italic>\n                    gene, that is, to the presence of three or four functional copies of the\n                    <jats:italic>Gldc<\/jats:italic>\n                    gene. The enzyme glycine decarboxylase (GLDC) degrades glycine, which is a co\u2010agonist at the NMDA receptor. In mice with 4 copies of\n                    <jats:italic>Gldc<\/jats:italic>\n                    , extracellular glycine concentrations have been reported to be reduced, while total glycine concentrations were unaltered. Here, we tested the hypothesis that chronically administered glycine could revert phenotypic changes observed in mice with 4 copies of\n                    <jats:italic>Gldc<\/jats:italic>\n                    . We found that 1.3\u2009g\/kg glycine administered in the drinking water reversed the startle habituation deficit, the spatial working memory deficit in Y\u2010maze, the sociability deficit and the latent inhibition deficit, while it had a minimal effect on the density of dendritic spines. We conclude that oral administration of glycine is sufficient to reverse some of the behavioral deficits in mice with 4 copies of\n                    <jats:italic>Gldc<\/jats:italic>\n                    but has a very limited effect on dendritic spine density.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70202","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T05:25:53Z","timestamp":1765257953000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Glycine Reverses Behavioral Deficits in a Mouse Model for Psychosis With 4 Copies of the\n                    <i>Gldc<\/i>\n                    Gene"],"prefix":"10.1002","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3021-4929","authenticated-orcid":false,"given":"Muxiao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Comparative Biosciences, College of Veterinary Medicine University of Illinois Urbana\u2010Champaign  Champaign Illinosis USA"},{"name":"Neuroscience Program University of Illinois Urbana\u2010Champaign  Champaign Illinosis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7635-5030","authenticated-orcid":false,"given":"Maltesh","family":"Kambali","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences, College of Veterinary Medicine University of Illinois Urbana\u2010Champaign  Champaign Illinosis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2775-0202","authenticated-orcid":false,"given":"Jinrui","family":"Lyu","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences, College of Veterinary Medicine University of Illinois Urbana\u2010Champaign  Champaign Illinosis USA"},{"name":"Neuroscience Program University of Illinois Urbana\u2010Champaign  Champaign Illinosis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3742-0709","authenticated-orcid":false,"given":"Rajasekar","family":"Nagarajan","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences, College of Veterinary Medicine University of Illinois Urbana\u2010Champaign  Champaign Illinosis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9396-4746","authenticated-orcid":false,"given":"Uwe","family":"Rudolph","sequence":"additional","affiliation":[{"name":"Department of Comparative Biosciences, College of Veterinary Medicine University of Illinois Urbana\u2010Champaign  Champaign Illinosis USA"},{"name":"Neuroscience Program University of Illinois Urbana\u2010Champaign  Champaign Illinosis USA"},{"name":"Carl R. Woese Institute for Genomic Biology University of Illinois Urbana\u2010Champaign  Champaign Illinosis USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2021.02.015"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.02.039"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2017.01.010"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23537"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166\u20102236(89)90042\u20108"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2020.20101481"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010024\u201002711\u20105"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004434\u20105"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586\u2010022\u201004556\u2010w"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/10673229609017192"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881120965937"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13204"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2008.130"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2014.05.015"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1304308110"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.04.031"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2013.06.013"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1990.01810140081011"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0361\u20109230(90)90241\u2010q"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471142301.ns0817s24"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104939\u20108994\u20102_10"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbi005"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1370\u201015.2015"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386\u2010021\u201001144\u2010w"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0107591"},{"key":"e_1_2_11_27_1","volume-title":"Design and Analysis of Experiments","author":"Montgomery D. C.","year":"2017"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.5812\/ijem.3505"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.2307\/2529511"},{"key":"e_1_2_11_30_1","volume-title":"Nonparametric Statistical Methods","author":"Hollander M.","year":"2013"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymgme.2024.108496"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00726\u2010011\u20100950\u2010y"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1909458116"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006\u20108993(91)91436\u20105"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1098\u20101136(199909)27:3<239::aid\u2010glia5>3.0.co;2\u2010k"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0169\u2010328x(01)00225\u2010x"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201439561"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25169040"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3257"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07239"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07229"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2016.03.013"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.70202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T16:56:35Z","timestamp":1765817795000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.70202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/prp2.70202"],"URL":"https:\/\/doi.org\/10.1002\/prp2.70202","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2024-11-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70202"}}