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However, its therapeutic potential in glioma remains unexplored. Ferroptosis, a regulatory cell death pathway dependent on iron content mediated through lethal lipid peroxidation, has become a prospective method for targeted treatment of drug\u2010resistant malignant tumors. This study confirmed that PAE is a new inducer of ferroptosis in human glioma cells. Inhibition of glioma proliferation, migration, and invasion was observed. Mechanistically, PAE depletes lipid droplets (LDs) and amplifies cytotoxic lipid peroxides (LPO) and reactive oxygen species (ROS); caspase\u2010independent cell death was achieved. Crucially, ferroptosis inhibitors (ferrostatin\u20101, \u03b1\u2010tocopherol) reversed PAE's antineoplastic roles, confirming pathway specificity. 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