{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:05:59Z","timestamp":1771232759422,"version":"3.50.1"},"reference-count":151,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Vancomycin (VAN) remains the first\u2010line treatment for methicillin\u2010resistant, multidrug\u2010resistant gram\u2010positive bacterial infections, even among cancer patients. Patients with hematological malignancies (HMs) represent a unique population, whose physiological and pathological changes often differ from those of the general population. These variations may cause significant alterations in the in\u00a0vivo pharmacokinetics (PK) of VAN, causing unpredictable changes in the safety, efficacy, and bacterial resistance. Customized dosing of VAN (CD\n                    <jats:sub>van<\/jats:sub>\n                    ) offers potential solutions to these challenges. However, there is currently a lack of guideline\u2010based, consensus\u2010driven references, and limited research on the implementation of CD\n                    <jats:sub>van<\/jats:sub>\n                    in HM patients, particularly in adults. This review concentrates on adult HM patients and reviews studies on VAN PK in them (including population PK and its models), focusing on current mainstream and novel CD\n                    <jats:sub>van<\/jats:sub>\n                    technologies, including therapeutic drug monitoring\u2010guided, model\u2010guided, closed\u2010loop control systems, and artificial intelligence\u2010guided CD\n                    <jats:sub>van<\/jats:sub>\n                    technologies. The challenges faced in the broader implementation of these technologies and the promising solutions exploited, such as blockchain technology\u2010driven clinical decision support systems, are also discussed. Understanding the multifaceted aspects of PK research and personalized dosing of VAN in HM patients will help facilitate the rational treatment of VAN, in\u2010depth PK research, and the development of CD\n                    <jats:sub>van<\/jats:sub>\n                    techniques in HM patients.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70218","type":"journal-article","created":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T06:20:08Z","timestamp":1769840408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacokinetics and Customized Dosing of Vancomycin in Adult Patients With Hematological Malignancies: Status, Challenges, and Opportunities"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5951-7280","authenticated-orcid":false,"given":"Xiangqing","family":"Song","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Hunan Cancer Hospital, The 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-020-04197-x"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ekir.2020.12.039"},{"key":"e_1_2_14_4_1","first-page":"269","article-title":"Analysis of 26 Blood Biochemical Indexes in Patients With Hematological Malignancies","volume":"30","author":"Huang z.","year":"1996","journal-title":"Journal of Fujian Medical 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