{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:54:05Z","timestamp":1781585645587,"version":"3.54.5"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T00:00:00Z","timestamp":1779753600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100006662","name":"Ardabil University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006662","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Posterior capsule opacification (PCO) is a common post\u2010cataract surgery complication treated with Nd:YAG laser posterior capsulotomy, which may cause intraocular pressure (IOP) spikes and threaten vision. Brimonidine and apraclonidine are widely used to prevent such elevations. This prospective, double\u2010masked, randomized clinical trial evaluated the efficacy of topical dexmedetomidine, a novel ophthalmic drop, in preventing IOP rise after Nd:YAG laser treatment. A total of 111 eyes from 89 pseudophakic patients were randomized to receive dexmedetomidine 0.008% or brimonidine 0.2% one\u2009h before the procedure. Patients with glaucoma, baseline IOP &gt;\u200924\u2009mmHg, keratoconus, corneal edema, prior refractive\/corneal surgery, or unstable cardiovascular disease were excluded. IOP was measured with air\u2010puff tonometry at baseline, 30\u2009min, 4\u2009h, and 24\u2009h post\u2010laser. Baseline characteristics were comparable. In the dexmedetomidine group, mean IOP values were 16.3\u2009\u00b1\u20093.6, 14.8\u2009\u00b1\u20094.7, 17.1\u2009\u00b1\u20096.2, and 16.7\u2009\u00b1\u20094.5\u2009mmHg, while in the brimonidine group, they were 16.7\u2009\u00b1\u20092.9, 13.3\u2009\u00b1\u20093.9, 13.2\u2009\u00b1\u20095.5, and 14.2\u2009\u00b1\u20093.9\u2009mmHg, respectively. At 30\u2009min, brimonidine significantly reduced IOP (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.000), whereas dexmedetomidine did not (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.116). At 4 and 24\u2009h, IOP increased above baseline with dexmedetomidine but decreased with brimonidine (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.001 and\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.004). Dexmedetomidine was associated with more IOP spikes &gt;\u200910\u2009mmHg (9% vs. 2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.035) and IOP &gt;\u200930\u2009mmHg (7% vs. 2%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.09). No systemic or ocular side effects occurred. Although dexmedetomidine prevented acute IOP surges, its efficacy was inferior to brimonidine. Further studies should explore optimal dosing, formulations, and long\u2010term safety to clarify its prophylactic potential.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70227","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T04:14:58Z","timestamp":1779855298000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Prophylactic Effect of Dexmedetomidine 0.008% Versus Brimonidine 0.2% on\n                    <scp>IOP<\/scp>\n                    Elevation After Nd:\n                    <scp>YAG<\/scp>\n                    Laser Capsulotomy"],"prefix":"10.1002","volume":"14","author":[{"given":"Parisa","family":"Zakeri","sequence":"first","affiliation":[{"name":"Ardabil University of Medical Sciences  Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghodrat","family":"Akhavanakbari","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Ardabil University of Medical Sciences  Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Ojaghi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Ardabil University of Medical Sciences  Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firouz","family":"Amani","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Biostatistics Ardabil University of Medical Sciences  Ardabil Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,26]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/08164622.2021.1989265"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-020-00973-4"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10028-1225"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp-journals-10078-1310"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/IJG.0000000000001621"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/aer.AER_100_17"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6186832"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.5812\/aapm.100673"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0259-1162.113987"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_1152_20"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2024.07.011"},{"key":"e_1_2_14_13_1","unstructured":"G.HornandGoogle Patents Assignee \u201cCompositions and Methods for Treatment of Glaucoma \u201dhttps:\/\/patents.google.com\/patent\/US8445526B2\/en(2013)."},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2006.04.014"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1076\/ceyr.25.4.237.13484"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-007-9101-6"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2006.22.176"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fvets.2024.1407928"},{"issue":"1","key":"e_1_2_14_19_1","first-page":"14","article-title":"Evaluation of the Effects of Medetomidine and Dexmedetomidine Use on Intraocular Pressure in Cats","volume":"6","author":"Karsl\u0131 B.","year":"2023","journal-title":"International Journal of Veterinary and Animal Research (IJVAR)"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2013.0174"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.2009.01852.x"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/IJO.IJO_694_23"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.70227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/prp2.70227","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.70227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:21:41Z","timestamp":1781583701000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.70227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,26]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/prp2.70227"],"URL":"https:\/\/doi.org\/10.1002\/prp2.70227","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,26]]},"assertion":[{"value":"2025-08-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70227"}}