{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,8]],"date-time":"2026-06-08T03:59:50Z","timestamp":1780891190004,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:00:00Z","timestamp":1775433600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100005378","name":"Hacettepe \u00dcniversitesi","doi-asserted-by":"publisher","award":["Project ID:19643"],"award-info":[{"award-number":["Project ID:19643"]}],"id":[{"id":"10.13039\/501100005378","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Colchicine is an ancient medication that has long been used for anti\u2010inflammatory properties. Because of unfavorable and toxic consequences of colchicine, selecting an appropriate dose is critical. The effects of three different doses (0.5, 1 or 5\u2009mg\/kg) of colchicine were evaluated. To stimulate systemic inflammation, we created an LPS\u2010induced experimental endotoxemia model with 1\u2009mg\/kg LPS intraperitoneal injection. Possible therapeutic effects of colchicine were investigated on cytokines, decreased mesenteric artery blood flow and histopathological damage scores. Treatment with 1\u2009mg\/kg colchicine reduced the pro\u2010inflammatory cytokines IL\u20101\u03b2, TNF\u2010\u03b1, IL\u20108, and IL\u201017 to levels comparable to the control group and attenuated the damage caused by LPS in liver and spleen tissues. At a dose of 0.5\u2009mg\/kg, colchicine was not able to decrease cytokine levels to those of the control group. In contrast, administration of 5\u2009mg\/kg colchicine ameliorated mesenteric blood flow; however, this higher dose caused an increase in cytokine levels. Among three different colchicine doses, 1\u2009mg\/kg intraperitoneal dose significantly improved the inflammatory indices and may be considered a suitable option for anti\u2010inflammatory treatment.<\/jats:p>","DOI":"10.1002\/prp2.70239","type":"journal-article","created":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T07:10:33Z","timestamp":1775459433000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Colchicine has Dose\u2010Dependent Therapeutic Effects in a\n                    <scp>LPS<\/scp>\n                    \u2010Induced Experimental Endotoxemia Model"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9790-1819","authenticated-orcid":false,"given":"Meliksah","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Medical Pharmacology Hacettepe University, Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayse Yesim","family":"Gocmen","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology Hacettepe University, Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esin","family":"Ozcelebi","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology Hacettepe University, Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuleyha","family":"Doganyigit","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Bozok University  Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131 Okan","family":"Oflamaz","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Bozok University  Yozgat Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7258-8902","authenticated-orcid":false,"given":"Alper Bektas","family":"Iskit","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology Hacettepe University, Faculty of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.20097"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20160090"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(99)00432-X"},{"issue":"10","key":"e_1_2_10_5_1","first-page":"953","article-title":"Colchicine intoxication: report of two suicide cases and review of the literature","volume":"24","author":"Iskit A. 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