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We examined reward\u2010related impulsive behavior, anxiety\u2010like behavior, locomotor activity and social behavior in the absence and presence of protracted pharmacological positive modulation of \u03b15\u2010 and \u03b16\u2010GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptors (GL\u2010II\u201073 and DK\u2010I\u201056\u20101, respectively) in male Sprague\u2013Dawley rats exposed to a combination of maternal deprivation (MD) and single prolonged stress (SPS). While locomotor and anxiety\u2010like behavior were not affected in the SPS and MD+SPS groups, the double\u2010hit group treated with DK\u2010I\u201056\u20101 exhibited a higher locomotor distance compared with MD+SPS and a higher percentage of open\u2010arm time in the elevated plus maze compared with the control group. In the variable delay\u2010to\u2010signal task of impulsivity, the total number of successful trials and premature responses (PR) in the first stage of the test day were reduced in all groups exposed to stress compared with the controls. Based on PR rates in the first and second set of trials, motor impulsivity was apparently suppressed in all stressed groups, while delay intolerance was suppressed only in the MD+SPS+GL\u2010II\u201073 group, respectively. In the three\u2010chamber test, social interaction was completely normal, while social recognition was preserved in the MD+SPS+GL\u2010II\u201073 group. In the resident\u2010intruder test, social play was reduced only in the SPS group. The evaluation of impulsive behavior in the used complex task was hindered by the lack of motivation of stressed rats, which in the case of omission percentage was ameliorated by positive modulation of \u03b15 and \u03b16 GABA\n                    <jats:sub>A<\/jats:sub>\n                    receptors.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70245","type":"journal-article","created":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T13:12:19Z","timestamp":1776431539000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Behavioral Domain\u2010Specific Effects of Positive Modulation of \u03b15 and \u03b16\n                    <scp>\n                      GABA\n                      <sub>A<\/sub>\n                    <\/scp>\n                    Receptors in a Rat Double\u2010Hit Stress Model"],"prefix":"10.1002","volume":"14","author":[{"given":"\u0110or\u0111e","family":"\u0110orovi\u0107","sequence":"first","affiliation":[{"name":"Institute of Anatomy \u201cNiko Miljani\u0107\u201d, School of Medicine University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovana","family":"Aran\u0111elovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Ivanovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Jezdi\u0107","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Pharmacy University of Belgrade  Belgrade 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