{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T18:26:26Z","timestamp":1788027986422,"version":"build-2784847793"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Drug information centers (DICs) are institutions dedicated to providing independent and up\u2010to\u2010date information on medications and their usage to healthcare professionals. Here, we provide an update from the clinical\u2010pharmacological DIC of Hannover Medical School, covering the period from April 2022 to December 2024. In total, 438 queries were evaluated. Potential differences between patient\u2010specific and general queries were analyzed with Pearson's chi\u2010squared test or Fisher's exact test. The Holm\u2013Bonferroni method was applied to counteract the problem of multiple comparisons. A curated selection of ten clinically interesting and educational queries is presented and discussed. 85.2% of the queries were patient\u2010specific, and 95.7% were submitted by physicians, predominantly internists, psychiatrists, and surgeons. Indications\/contraindications, adverse drug reactions, and pharmacodynamic interactions (PDIs) represented the three most frequent query categories. Compared to our previous research, we observed increases in queries about pharmacotherapy in advanced age and drug use during pregnancy or breastfeeding. As compared to general queries, patient\u2010specific queries were significantly more often related to indications\/contraindications (26.2% vs. 49.6%;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) and PDIs (24.6% vs. 44.5%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.003) after adjusting for multiple comparisons. The query characteristics remained relatively stable between our previous investigation and the current analysis (2022\u20132024), in particular with respect to type of queries, profession of inquiring healthcare professionals, medical specialties of inquirers, and query categories. Changes mainly pertained to higher proportions of queries about pharmacotherapy in advanced age and drug use during pregnancy or breastfeeding.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70247","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T04:09:51Z","timestamp":1775707791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Clinical\u2010Pharmacological Drug Information Center of Hannover Medical School: Update From a Tertiary Care University Hospital (2022\u20132024)"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5382-3014","authenticated-orcid":false,"given":"Johannes","family":"Heck","sequence":"first","affiliation":[{"name":"Institute for Clinical Pharmacology Hannover Medical School  Hannover Germany"},{"name":"Institute for General Practice and Palliative Care Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6526-0917","authenticated-orcid":false,"given":"Dirk O.","family":"Stichtenoth","sequence":"additional","affiliation":[{"name":"Institute for Clinical Pharmacology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3541-8987","authenticated-orcid":false,"given":"Christoph","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Institute for Clinical Pharmacology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra","family":"Sabau","sequence":"additional","affiliation":[{"name":"Institute for Clinical Pharmacology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2786-6698","authenticated-orcid":false,"given":"Anna\u2010Leena K.","family":"Heim","sequence":"additional","affiliation":[{"name":"Institute for Clinical Pharmacology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7378-7877","authenticated-orcid":false,"given":"Felix","family":"Koop","sequence":"additional","affiliation":[{"name":"Institute for Clinical Pharmacology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1031-1913","authenticated-orcid":false,"given":"Thorben","family":"Pape","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine and Infectious Diseases Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0905-274X","authenticated-orcid":false,"given":"Sebastian","family":"Schr\u00f6der","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry and Psychotherapy Hannover Medical School  Hannover Germany"},{"name":"PRACTIS Clinician Scientist Program, Dean's Office for Academic Career Development Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3262-8137","authenticated-orcid":false,"given":"Martin Schulze","family":"Westhoff","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Social Psychiatry and Psychotherapy Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5899-0113","authenticated-orcid":false,"given":"Benjamin","family":"Krichevsky","sequence":"additional","affiliation":[{"name":"Institute for General Practice and Palliative Care Hannover Medical School  Hannover Germany"},{"name":"Interdisciplinary Emergency Department University Hospital Schleswig\u2010Holstein  Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3054-9905","authenticated-orcid":false,"given":"Martin","family":"Klietz","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0638-8571","authenticated-orcid":false,"given":"Stephan","family":"Greten","sequence":"additional","affiliation":[{"name":"Department of Neurology Hannover Medical School  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3012-4245","authenticated-orcid":false,"given":"Carsten","family":"Schumacher","sequence":"additional","affiliation":[{"name":"Institute for Clinical Pharmacology Hannover Medical School  Hannover Germany"},{"name":"Center for Clinical Trials Hannover Medical School  Hannover 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