{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:54:19Z","timestamp":1781585659447,"version":"3.54.5"},"reference-count":70,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Podocarpus neriifolius<\/jats:italic>\n                    <\/jats:styled-content>\n                    , a widely distributed medicinal plant in South and Southeast Asia, has traditionally been used to treat rheumatism and joint pain. This study aimed to investigate the phytochemical profile and therapeutic potential of the ethanolic leaf extract of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. neriifolius<\/jats:italic>\n                    <\/jats:styled-content>\n                    (EEPN) using integrated in\u00a0vitro, in\u00a0vivo, and\n                    <jats:italic>in silico<\/jats:italic>\n                    approaches. Phytochemical analysis via FT\u2010IR and GC\u2013MS revealed the presence of steroidal glycosides, flavonoids, alkenes, aliphatic compounds, steroids, saponins, and other glycosides. In a COX inhibition assay, EEPN demonstrated notable in\u00a0vitro anti\u2010inflammatory effects, further validated in a mouse paw edema test. In Swiss albino mice, EEPN (200 and 400\u2009mg\/kg) showed increased head dipping in HBT (43.4\u2009\u00b1\u20091.14 and 69.2\u2009\u00b1\u20091.22), where the standard showed (57.5\u2009\u00b1\u20091.01), and improved open\u2010arm entries and time in EPM (260.3 and 280.6\u2009s) compared to the standard (245.2\u2009s). EEPN produced a dose\u2010dependent sedative effect both in HCT and OFT. Furthermore, EEPN significantly lowered immobility time in the tail suspension and forced swimming tests, demonstrating its antidepressant effects. According to molecular docking studies, the phytochemicals in EEPN showed a strong affinity for binding to important drug target proteins linked to inflammation, anxiety, and depression. The EEPN had binding affinities of \u22126.6, \u22125.4, and \u221210\u2009kcal\/mol with COX2, GABA\n                    <jats:sub>A<\/jats:sub>\n                    , and the serotonin transporter, respectively. Protein\u2010ligand complex stability was validated through molecular dynamics simulations analysis. The pharmacokinetic and safety profile of the compounds in ADMET analysis showed druggable qualities within acceptable ranges, implying the possibility as potential medications in the future. However, further research is necessary to ascertain whether\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>P. neriifolius<\/jats:italic>\n                    <\/jats:styled-content>\n                    leaves can be utilized as a therapeutic agent.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70272","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:03:56Z","timestamp":1780463036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the Phytochemical Constituents, Anti\u2010Inflammatory, and Neuropharmacological Activities of\n                    <i>Podocarpus neriifolius<\/i>\n                    Leaves Through\n                    <scp>FT<\/scp>\n                    \u2010\n                    <scp>IR<\/scp>\n                    ,\n                    <scp>GC<\/scp>\n                    \u2013\n                    <scp>MS<\/scp>\n                    , Experimental Studies, Molecular Docking, and Molecular Dynamics Simulations"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-3704-7945","authenticated-orcid":false,"given":"Neamul","family":"Hoque","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Tashrif Rahman","family":"Tipu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Abul","family":"Bashar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences Islamic University  Kushtia Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raju","family":"Dash","sequence":"additional","affiliation":[{"name":"Department of New Biology Daegu Gyeongbuk Institute of Science and Technology (DGIST)  Daegu Republic of Korea"},{"name":"InnoCORE AI\u2010CRED Institute Korea Advanced Institute of Science and Technology (KAIST)  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kutub Uddin","family":"Ahamed","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Division, BCSIR Dhaka Laboratories Bangladesh Council of Scientific and Industrial Research (BCSIR)  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-1945-6598","authenticated-orcid":false,"given":"Md. Liakot","family":"Ali","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1926-6407","authenticated-orcid":false,"given":"Md. Jahirul Islam","family":"Mamun","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bakul","family":"Akter","sequence":"additional","affiliation":[{"name":"School of Pharmacy BRAC University  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Kamrul","family":"Hossain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5877-8638","authenticated-orcid":false,"given":"Nawreen Monir","family":"Proma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Faculty of Biological Sciences University of Chittagong  Chittagong Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2249.2006.03261.x"},{"issue":"1","key":"e_1_2_11_3_1","first-page":"7","article-title":"The Role of Free Radicals in the Pathogenesis of Rheumatoid Arthritis","volume":"45","author":"Hadjigogos K.","year":"2003","journal-title":"Panminerva Medica"},{"issue":"2","key":"e_1_2_11_4_1","first-page":"111","article-title":"In Vitro Erythrocyte Membrane Stabilization Properties of \n                     Solanum aethiopicum\n                   L. 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