{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:54:03Z","timestamp":1781585643962,"version":"3.54.5"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T00:00:00Z","timestamp":1780358400000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Despite widespread use, real\u2010world evidence regarding proton pump inhibitor (PPI) prescribing and rationalization practices in Southeast Asia (SEA) remains limited; therefore, we aimed to characterize current prescribing behaviors and rationalization strategies among healthcare professionals in the region. The SEA PPI Rationalisation Working Group developed and disseminated an online questionnaire via professional networks across SEA to collect data on respondent demographics, PPI prescribing practices, and rationalization approaches; instrument reliability testing produced a Cronbach's\n                    <jats:italic>\u03b1<\/jats:italic>\n                    of 0.799 and content validity was confirmed by a panel of 10 gastroenterology experts with complete agreement on relevance and clarity (I\u2010CVI, kappa, SCVI\/Ave\u2009=\u20091.0). K\u2010mode clustering was applied to delineate prescribing patterns. Of 869 responses received, 763 valid entries were analyzed (response rate 87.8%), 49% of whom were gastroenterologists. PPIs were most frequently prescribed for gastroesophageal reflux disease (67.8%) and peptic ulcer disease (43.8%); 48.9% of respondents reported long\u2010term PPI use, while 59.2% reported reassessment of indications at every follow\u2010up visit. Common rationalization strategies comprised dose tapering (46.8%), on\u2010demand administration (45.9%), and step\u2010down to antacids or alginates (44.8%). Cluster analysis identified two distinct prescriber profiles: proactive prescribers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009326, 42.7%), who adhered to clinical guidelines, implemented individualized dosing, and routinely reassessed therapy; and conservative prescribers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009437, 57.3%), who employed PPIs more restrictively and engaged less frequently in rationalization. The considerable variability in PPI prescribing and rationalization practices across SEA underscores the need for a regional consensus to promote evidence\u2010based practice.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70274","type":"journal-article","created":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T04:27:00Z","timestamp":1780460820000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Proton Pump Inhibitors Prescribing Behaviors and Rationalization Strategies Among Healthcare Providers in Southeast Asia"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0141-921X","authenticated-orcid":false,"given":"Duc Trong","family":"Quach","sequence":"first","affiliation":[{"name":"Department of Internal Medicine and Gastro\u2010Hepato Integrated Research Team (GHIRT\u2010002.TCM2025) University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"},{"name":"Department of Gastroenterology Nhan Dan Gia Dinh Hospital  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8233-8202","authenticated-orcid":false,"given":"Tien Manh","family":"Huynh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Gastro\u2010Hepato Integrated Research Team (GHIRT\u2010002.TCM2025) University of Medicine and Pharmacy at Ho Chi Minh City  Ho Chi Minh City Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4930-0318","authenticated-orcid":false,"given":"Augusto Jose G.","family":"Galang","sequence":"additional","affiliation":[{"name":"Section of Gastroenterology, Department of Medicine Angeles University Foundation Medical Center  Angeles City Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-9496","authenticated-orcid":false,"given":"Hang Viet","family":"Dao","sequence":"additional","affiliation":[{"name":"Internal Medicine Faculty, Endoscopy Centre Hanoi Medical University, Hanoi Medical University Hospital  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6924-8504","authenticated-orcid":false,"given":"Sakkarin","family":"Chirapongsathorn","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Phramongkutklao Hospital and College of Medicine  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3186-8107","authenticated-orcid":false,"given":"Phuripong","family":"Kijdamrongthum","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1694-0692","authenticated-orcid":false,"given":"Rahela Ambaras","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Hospital Kuala Lumpur, Ministry of Health  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9199-2038","authenticated-orcid":false,"given":"Andrew Ming\u2010Liang","family":"Ong","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Singapore General Hospital  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7539-0918","authenticated-orcid":false,"given":"Wee Kooi","family":"Cheah","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Research Center Hospital Taiping  Taiping Perak Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2994-666X","authenticated-orcid":false,"given":"Kalwinder Singh","family":"Khaira","sequence":"additional","affiliation":[{"name":"Department of Medicine Sarawak General Hospital  Kuching Sarawak Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-3316-7054","authenticated-orcid":false,"given":"So Fie","family":"Tan","sequence":"additional","affiliation":[{"name":"Regional Medical Science Reckitt Benckiser (M) Sdn. Bhd  Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3227-1983","authenticated-orcid":false,"given":"Jose","family":"Sollano","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Surgery University of Santo Tomas  Manila Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0041-3553","authenticated-orcid":false,"given":"Ari Fahrial","family":"Syam","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine Faculty of Medicine Universitas Indonesia\u2014Cipto Mangunkusumo General Hospital  Jakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6525-9141","authenticated-orcid":false,"given":"Tju Siang","family":"Chua","sequence":"additional","affiliation":[{"name":"AliveoMedical  Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7104-2759","authenticated-orcid":false,"given":"Somchai","family":"Leelakusolvong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Medicine Faculty of Medicine Siriraj Hospital, Mahidol University  Bangkok Thailand"},{"name":"Siriraj GI Endoscopy Center, Siriraj Hospital  Bangkok Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6486-7717","authenticated-orcid":false,"given":"Yeong Yeh","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Malaysia"},{"name":"Department of Internal Medicine, Faculty of Medicine, Dr. Soetomo Teaching Hospital Universitas Airlangga  Surabaya Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39406.449456.BE"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/21501327211035088"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11096\u2010019\u201000955\u20108"},{"key":"e_1_2_12_5_1","first-page":"1043","article-title":"Appropriateness of Proton Pump Inhibitors Prescription in Patients Admitted to a Malaysian Tertiary Hospital","volume":"9","author":"Fah T. 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