{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:54:09Z","timestamp":1781585649627,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This prospective observational study investigated the acute effects of a single 10\u2009mg dose of methylphenidate (MPH) on hemodynamic and electrocardiographic parameters in 60 children aged 6\u201316\u2009years newly diagnosed with Attention Deficit Hyperactivity Disorder (ADHD). All participants received 10\u2009mg short\u2010acting MPH, and systolic and diastolic blood pressure, heart rate, and electrocardiographic measurements (QTc, PR, QRS intervals, and rhythm) were obtained both before and 30\u201345\u2009min after administration under standardized conditions and interpreted by a pediatric cardiologist. Following MPH intake, significant increases were observed in systolic blood pressure (105.0\u2009\u00b1\u20097.7 to 110.1\u2009\u00b1\u20098.9\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), diastolic blood pressure (69.3\u2009\u00b1\u20099.2 to 73.4\u2009\u00b1\u20099.8\u2009mmHg,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), and heart rate (79.8\u2009\u00b1\u20099.0 to 84.9\u2009\u00b1\u20099.8\u2009bpm,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). QTc (395.9\u2009\u00b1\u200911.6 to 401.0\u2009\u00b1\u200912.5\u2009ms), PR (135.8\u2009\u00b1\u200916.8 to 140.9\u2009\u00b1\u200916.7\u2009ms), and QRS durations (91.1\u2009\u00b1\u20099.5 to 93.6\u2009\u00b1\u20099.5\u2009ms) also showed significant prolongation (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). Post\u2010treatment ECG rhythm abnormalities were observed in 15.0% of participants (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.002), including sinus tachycardia, sinus arrhythmia, and isolated premature atrial or ventricular beats, with markedly higher prevalence among those below the 5th BMI percentile (75.0%,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001), whereas no rhythm disturbances were detected in the 5th\u201385th percentile group. These findings indicate that MPH induces acute but measurable cardiovascular changes in children with ADHD, particularly in underweight children, underscoring the need for ECG and blood pressure monitoring during treatment initiation.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70276","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T03:50:08Z","timestamp":1780631408000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigation of the Effects of Methylphenidate on Hemodynamic Parameters in Children With\n                    <scp>ADHD<\/scp>"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4428-6912","authenticated-orcid":false,"given":"Caglar Charles Daniel","family":"Jaicks","sequence":"first","affiliation":[{"name":"Department of Child and Adolescent Psychiatry Istanbul Aydin University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selman Vefa","family":"Y\u0131ld\u0131r\u0131m","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology Near East University  Nicosia Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/15374416.2024.2335625"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2019-2528"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/10870547211012039"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2024-065787"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2022.114492"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-023-05370-w"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/10870547231214993"},{"issue":"20","key":"e_1_2_9_9_1","first-page":"2382","article-title":"Methylphenidate Versus Placebo for Treating Fatigue in Patients With Advanced Cancer: Randomized, Double\u2010Blind, Multicenter, Placebo\u2010Controlled Trial","volume":"42","author":"Stone P. 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