{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:54:14Z","timestamp":1781585654578,"version":"3.54.5"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This prospective study compared the Marsh and Schnider pharmacokinetic models for propofol target\u2010controlled infusion (TCI) during anesthetic induction in obese patients undergoing elective cardiac surgery. A total of 118 patients were randomly assigned to either the Marsh or Schnider group (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200959 each). The primary outcome was the performance error (\u0394C\u2009=\u2009measured minus predicted plasma concentration) during and after TCI. Secondary outcomes included hemodynamic pharmacokinetic\u2010pharmacodynamic (PK\u2010PD) model, anesthetic depth (BIS), cardiac function (LVEF, SV), electrocardiographic PK\u2010PD model (QTc, QTcd), and recovery profiles. While no significant differences in \u0394C were observed during TCI, the Marsh model demonstrated significantly lower \u0394C at all time points after TCI cessation (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Compared to the Schnider group, the Marsh group also showed higher BIS values, better preserved LVEF and SV, shorter QTc\/QTcd intervals, reduced propofol requirements, and shorter recovery times (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). In conclusion, under the conditions of this study, in which propofol TCI was configured using total body weight for the Marsh model and lean body weight for the Schnider model, the Marsh model provided more accurate plasma concentration control, better hemodynamic stability, and improved recovery profiles compared with the Schnider model for anesthetic induction in obese cardiac surgery patients.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70284","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T04:02:57Z","timestamp":1781323377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Prospective Study of Marsh\n                    <scp>PK<\/scp>\n                    \u2010\n                    <scp>PD<\/scp>\n                    Model and Schnider\n                    <scp>PK<\/scp>\n                    \u2010\n                    <scp>PD<\/scp>\n                    Model During Anesthesia Induction for Obese Patients Undergoing Elective Heart Surgery"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7060-614X","authenticated-orcid":false,"given":"Jianhong","family":"Ye","sequence":"first","affiliation":[{"name":"Department of Anesthesiology The First Hospital of Nanping Affiliated to Fujian Medical University  Nanping City China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-6589-5523","authenticated-orcid":false,"given":"Weina","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Xinchang Hospital of Wenzhou Medical University  Shaoxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40256-019-00365-1"},{"issue":"8","key":"e_1_2_11_3_1","first-page":"749","article-title":"The Effectiveness and Safety of Precision Cardiac Anesthesia in Patients Undergoing Cardiac Surgery","volume":"40","author":"Gao Y. C.","year":"2019","journal-title":"International Journal of Anesthesiology and Resuscitation"},{"issue":"24","key":"e_1_2_11_4_1","first-page":"4145","article-title":"Effect and Safety Evaluation of Propofol With Different Anesthetic Induction Doses on Cardiac Pump Function in Morbidly Obese Patients","volume":"33","author":"Liao W. H.","year":"2017","journal-title":"Journal of Practical Medicine"},{"issue":"10","key":"e_1_2_11_5_1","first-page":"91","article-title":"The Application of Target Controlled Infusion With Propofol by Marsh Model Versus Schnider Model During Gynecological Laparoscopic Surgery","volume":"15","author":"Wei H.","year":"2018","journal-title":"China Medical Herald"},{"issue":"2","key":"e_1_2_11_6_1","first-page":"387","article-title":"Research Progress on Pharmacokinetics and Target\u2010Controlled Infusion Model of Propofol","volume":"35","author":"Chen G. M.","year":"2020","journal-title":"Drugs & Clinic"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACO.0000000000000619"},{"issue":"1","key":"e_1_2_11_8_1","first-page":"131","article-title":"Effect of Excessive Head\u2010Down Laparoscopic Surgery on Hemodynamics and Cardiac Function in Obese Patients","volume":"22","author":"Li Z. P.","year":"2020","journal-title":"Zhejiang Clinical Medical Journal"},{"issue":"8","key":"e_1_2_11_9_1","first-page":"810","article-title":"Anesthesia Effect of Two Propofol Pharmacokinetic Models by Target\u2010Controlled Infusion in Patients at Middle Altitude","volume":"36","author":"Shen G. C.","year":"2020","journal-title":"Journal of Clinical Anesthesiology"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.21315\/mjms2018.25.1.4"},{"issue":"4","key":"e_1_2_11_11_1","first-page":"582","article-title":"The Application of Target Controlled Infusion With Propofol by Marsh Model Versus Schnider Model During Hyperthermic Intraperitoneal Chemotherapy","volume":"23","author":"Han Y.","year":"2019","journal-title":"Chinese Journal of Laboratory Diagnosis"},{"issue":"6","key":"e_1_2_11_12_1","first-page":"698","article-title":"The Application of Target Controlled Infusion With Propofol by Marsh Model Versus Schnider Model During Hysteroscopic Surgery","volume":"18","author":"Li L.","year":"2018","journal-title":"Lingnan Modern Clinics in Surgery"},{"key":"e_1_2_11_13_1","volume-title":"Clinical Study and Evaluation of Propofol BIS Closed\u2010Loop Target\u2010Controlled Infusion System","author":"Zhao S. W.","year":"2017"},{"issue":"1","key":"e_1_2_11_14_1","first-page":"95","article-title":"Research Progress of Closed\u2010Loop Target\u2010Controlled Infusion System in Clinical Anesthesia","volume":"37","author":"Zhou R. H.","year":"2021","journal-title":"Journal of Clinical Anesthesiology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.13335"},{"issue":"7","key":"e_1_2_11_16_1","first-page":"88","article-title":"Influence of Sevoflurane on Perioperative Hemodynamics and Myocardium in Elderly Patients With Coronary Heart Disease","volume":"28","author":"Wang Y. Y.","year":"2018","journal-title":"China Journal of Modern Medicine"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13781"},{"issue":"2","key":"e_1_2_11_18_1","first-page":"233","article-title":"Effect of Anesthetic Drugs on Cardiac Muscle Cells After Chemotherapy in Patients With Breast Cancer","volume":"17","author":"Liu Z. M.","year":"2017","journal-title":"Journal of Tropical Medicine"},{"issue":"2","key":"e_1_2_11_19_1","first-page":"214","article-title":"Effects of Different Concentrations of Desflurane on Electrocardiographic QTc,QTd,QTcd,Tp\u2010e and Tp\u2010e\/QT in Patients With Gynecologic Surgery","volume":"45","author":"Liu Y. Q.","year":"2020","journal-title":"Journal of Guizhou Medical University"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.70284","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/prp2.70284","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.70284","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T04:20:32Z","timestamp":1781583632000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.70284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/prp2.70284"],"URL":"https:\/\/doi.org\/10.1002\/prp2.70284","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"2025-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70284"}}