{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T14:18:38Z","timestamp":1787840318273,"version":"build-2784847793"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025MS1445"],"award-info":[{"award-number":["ZR2025MS1445"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2025QC881"],"award-info":[{"award-number":["ZR2025QC881"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp;amp; Perspec"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>LPM7100328 is a novel oral GnRH antagonist being developed for the prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The studies presented herein reported assessment of safety in favor of human clinical trials. Safety pharmacology studies showed that LPM7100328 had no adverse pharmacological effects. No apparent abnormalities were observed in 28\u2010day rat and dog toxicity study, the no observed adverse effect level (NOAEL) was 100\u2009mg\/kg and 50\u2009mg\/kg, respectively. LPM7100328 was found to be non\u2010genotoxic in the Ames, aberration test or micronucleus assay. In the rat fertility and early embryonic development study and rabbit fertility and embryo\u2010fetal development study, LPM7100328 demonstrated a generally favorable safety profile, with no teratogenic effects observed in\u00a0either species. And LPM7100328 showed no phototoxicity. Collectively, these findings indicate a favorable nonclinical safety profile for LPM7100328 in the prevention of premature LH surges during women undergoing controlled ovarian stimulation.<\/jats:p>","DOI":"10.1002\/prp2.70312","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:20:13Z","timestamp":1787836813000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preclinical and Toxicology Studies of\n                    <scp>LPM7100328<\/scp>\n                    , a Novel Oral\n                    <scp>GnRH<\/scp>\n                    Antagonist"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0489-5209","authenticated-orcid":false,"given":"Yao","family":"Wang","sequence":"first","affiliation":[{"name":"Key Laboratory of Molecular Pharmacology and Drug Evaluation, School of Pharmacy, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong Yantai University  Yantai Shandong China"},{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems Shandong Luye Pharmaceutical Co. Ltd.  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Beijing Peking University WBL Biotech Co. Ltd.  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangxia","family":"Zou","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Pharmacology and Drug Evaluation, School of Pharmacy, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong Yantai University  Yantai Shandong China"},{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems Shandong Luye Pharmaceutical Co. Ltd.  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanglin","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems Shandong Luye Pharmaceutical Co. Ltd.  Yantai Shandong China"},{"name":"School of Pharmacy Shandong Medical and Pharmaceutical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianzhao","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems Shandong Luye Pharmaceutical Co. Ltd.  Yantai Shandong China"},{"name":"College of Life Sciences Yantai University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Yu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems Shandong Luye Pharmaceutical Co. Ltd.  Yantai Shandong China"},{"name":"Department of Clinical Medicine Shandong Medical and Pharmaceutical University  Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Ye","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems Shandong Luye Pharmaceutical Co. Ltd.  Yantai Shandong China"},{"name":"School of Public Health and Management Shandong Medical and Pharmaceutical University  Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Pharmacology and Drug Evaluation, School of Pharmacy, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong Yantai University  Yantai Shandong China"},{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems Shandong Luye Pharmaceutical Co. Ltd.  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Yantai Shandong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwei","family":"Tian","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Pharmacology and Drug Evaluation, School of Pharmacy, Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong Yantai University  Yantai Shandong China"},{"name":"State Key Laboratory of Advanced Drug Delivery and Release Systems Shandong Luye Pharmaceutical Co. Ltd.  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