{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T06:45:16Z","timestamp":1792133116862,"version":"4.4.0"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2026,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Residual cardiovascular risk persists in patients with adequately controlled hypertension, driven partly by inflammation, oxidative stress and endothelial dysfunction. Chios mastic (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Pistacia lentiscus<\/jats:italic>\n                    <\/jats:styled-content>\n                    var.\n                    <jats:italic>Chia<\/jats:italic>\n                    ) has shown antihypertensive, antioxidant and vascular effects in experimental and clinical settings. This trial evaluated whether Chios mastic supplementation confers additional cardiovascular benefits in well\u2010controlled hypertensive individuals. In this double\u2010blind, randomized, placebo\u2010controlled trial, 106 adults with stable, well\u2010controlled hypertension and variable cardiovascular risk, based on SCORE2, received low\u2010dose Chios mastic (1500\u2009mg\/day), high\u2010dose Chios mastic (2800\u2009mg\/day) or placebo for 3\u2009months. Primary endpoints were changes in 24\u2010h ambulatory systolic and diastolic blood pressure. Secondary endpoints included vascular function, oxidative stress and proteasome activity in peripheral blood mononuclear cells and red blood cells. Transcriptomic profiling was performed in a predefined high\u2010risk subgroup. Chios mastic supplementation was well tolerated, with high adherence confirmed by dose\u2010dependent increases in plasma masticadienonic and isomasticadienonic acids. No significant between\u2010group differences were observed in 24\u2010h systolic or diastolic blood pressure after the intervention. Oxidative stress markers and proteasome activity remained unchanged across groups. In high\u2010risk participants, mastic supplementation induced distinct transcriptomic changes, particularly in pathways related to endothelial junction organization and vascular integrity. Overall, in adults with well\u2010controlled hypertension and low baseline cardiovascular risk, Chios mastic supplementation did not lower blood pressure over 3\u2009months, likely reflecting a ceiling effect. Transcriptomic findings suggest biologically meaningful vascular effects in individuals with higher residual cardiovascular risk, supporting future investigation in higher\u2010risk populations.\n                  <\/jats:p>","DOI":"10.1002\/prp2.70322","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T05:57:30Z","timestamp":1792130250000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Chios Mastic in Well\u2010Controlled Hypertension: Findings From the\n                    <scp>HYPER<\/scp>\n                    \u2010\n                    <scp>MASTIC<\/scp>\n                    Randomized Controlled Trial"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5572-7491","authenticated-orcid":false,"given":"Ioanna Panagiota","family":"Kalafati","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education Harokopio University of Athens  Athens Greece"},{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia\u2010Areti","family":"Kyriazopoulou\u2010Korovesi","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7965-155X","authenticated-orcid":false,"given":"Evangelia","family":"Mentsiou\u2010Nikolaou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education Harokopio University of Athens  Athens Greece"},{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4268-3527","authenticated-orcid":false,"given":"Maria","family":"Papaioannou","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5937-4117","authenticated-orcid":false,"given":"Christina","family":"Konstantaki","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasthenis","family":"Angelidakis","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8111-6528","authenticated-orcid":false,"given":"Despoina D.","family":"Gianniou","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Biophysics, Faculty of Biology National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4033-5580","authenticated-orcid":false,"given":"Eleni V.","family":"Mikropoulou","sequence":"additional","affiliation":[{"name":"Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Giardoglou","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education Harokopio University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8905-9516","authenticated-orcid":false,"given":"Dimitrios","family":"Valakos","sequence":"additional","affiliation":[{"name":"Multi\u2010Omics Laboratory, Center of Systems Biology Biomedical Research Foundation of the Academy of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1631-1060","authenticated-orcid":false,"given":"Giannis","family":"Vatsellas","sequence":"additional","affiliation":[{"name":"Multi\u2010Omics Laboratory, Center of Systems Biology Biomedical Research Foundation of the Academy of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"HYPER\u2010MASTIC Consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioanna","family":"Andreadou","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmacology, Faculty of Pharmacy National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1449-6492","authenticated-orcid":false,"given":"Efstathios","family":"Manios","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5620-0165","authenticated-orcid":false,"given":"Maria","family":"Halabalaki","sequence":"additional","affiliation":[{"name":"Division of Pharmacognosy and Natural Products Chemistry, Department of Pharmacy National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6179-2772","authenticated-orcid":false,"given":"Ioannis P.","family":"Trougakos","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Biophysics, Faculty of Biology National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-6221","authenticated-orcid":false,"given":"George V.","family":"Dedoussis","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, School of Health Science and Education Harokopio University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimon","family":"Stamatelopoulos","sequence":"additional","affiliation":[{"name":"Department of Clinical Therapeutics, School of Medicine National and Kapodistrian University of Athens  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