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This effect is achieved by the two naturally occurring incretin hormones: glucose\u2010dependent insulinotropic polypeptide (GIP) and glucagon\u2010like peptide\u20101 (GLP\u20101). Such hormones released by specialized entero\u2010endocrine cells of the gastrointestinal tract cause insulin augmentation after food consumption. However, incretin effects are impaired in type 2 diabetic, primarily attributed to the deterioration of GLP\u20101 function along with decreased GLP\u20101 receptor expression. Targeting this hormone has, therefore, become an important therapeutic approach to treat this diabetic condition. Native GLP\u20101's brief half\u2010life and rapid proteolytic degradation have generated significant enthusiasm in uncovering the long\u2010acting GLP\u20101 receptor (GLP\u20101R) agonists to manage type 2 diabetes. These synthetic peptides mimic the natural GLP\u20101 to activate GLP\u20101R and effectively exert various physiological benefits in terms of weight management, blood pressure (BP), lipid profile, obesity and major adverse cardiovascular event. Although the BP\u2010lowering effect of GLP\u20101R agonists is well documented in clinical trials, the underlying molecular mechanisms remain incompletely defined, since most evidence comes from animal and in\u00a0vitro models rather than human studies. This gap limits translating the clinical benefit into targeted, mechanism\u2010based practice. This review paper provides insights into the structure, function and expression of GLP\u20101 and its receptor. It also summarizes existing literature regarding different types of GLP\u20101R agonists, their effects on BP and how they exert their actions. Evidence indicates GLP\u20101R agonists produce a modest, consistent reduction in systolic blood pressure, heterogeneous across agents and confined to patients with elevated baseline BP, reflecting vascular, renal and anti\u2010inflammatory mechanisms rather than a single pathway. Although animal models have contributed significantly to this area of study, the scarcity of human studies is noted, indicating a need for more investigation in this domain. Expanding research in humans will help in comprehending the impact of GLP\u20101R agonists on BP regulation and their underlying mechanisms.<\/jats:p>","DOI":"10.1002\/prp2.70329","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T04:13:17Z","timestamp":1791173597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Glucagon\u2010Like Peptide\u20101 Agonists and Blood Pressure Regulation: Molecular Mechanisms and Cardiovascular Implications"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4268-2552","authenticated-orcid":false,"given":"Nora H. 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