{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T12:33:41Z","timestamp":1784810021564,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T00:00:00Z","timestamp":1615507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Both antiviral treatment with remdesivir and hemoadsorption using a CytoSorb<jats:sup>\u00ae<\/jats:sup> adsorption device are applied in the treatment of severe COVID\u201019. The CytoSorb<jats:sup>\u00ae<\/jats:sup> adsorber consists of porous polymer beads that adsorb a broad range of molecules, including cytokines but also several therapeutic drugs. In this study, we evaluated whether remdesivir and its main active metabolite GS\u2010441524 would be adsorbed by CytoSorb<jats:sup>\u00ae<\/jats:sup>. Serum containing remdesivir or GS\u2010441524 was circulated in a custom\u2010made system containing a CytoSorb<jats:sup>\u00ae<\/jats:sup> device. Concentrations of remdesivir and GS\u2010441524 before and after the adsorber were analyzed by liquid chromatography\u2010tandem mass spectrometry. Measurements of remdesivir in the outgoing tube after the adsorber indicated almost complete removal of remdesivir by the device. In the reservoir, concentration of remdesivir showed an exponential decay and was not longer detectable after 60\u00a0mins. GS\u2010441524 showed a similar exponential decay but, unlike remdesivir, it reached an adsorption\u2013desorption equilibrium at ~48\u00a0\u00b5g\/L. Remdesivir and its main active metabolite GS\u2010441524 are rapidly eliminated from the perfusate by the CytoSorb<jats:sup>\u00ae<\/jats:sup> adsorber device <jats:italic>in vitro<\/jats:italic>. This should be considered in patients for whom both therapies are indicated, and simultaneous application should be avoided. In general, plasma levels of therapeutic drugs should be closely monitored under concurrent CytoSorb<jats:sup>\u00ae<\/jats:sup> therapy.<\/jats:p>","DOI":"10.1002\/prp2.743","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T11:04:44Z","timestamp":1615547084000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Hemoadsorption eliminates remdesivir from the circulation: Implications for the treatment of COVID\u201019"],"prefix":"10.1002","volume":"9","author":[{"given":"Paul","family":"Biever","sequence":"first","affiliation":[{"name":"Heart Center Freiburg University Department of Cardiology and Angiology I Faculty of Medicine University of Freiburg Freiburg Germany"},{"name":"Department of Medicine III (Interdisciplinary Medical Intensive Care) Medical Center Faculty of Medicine University of Freiburg Freiburg Germany"},{"name":"Department of Medicine II (Division of Infectious Diseases) Medical Center Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawid L.","family":"Staudacher","sequence":"additional","affiliation":[{"name":"Heart Center Freiburg University Department of Cardiology and Angiology I Faculty of Medicine University of Freiburg Freiburg Germany"},{"name":"Department of Medicine III (Interdisciplinary Medical Intensive Care) Medical Center Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela J.","family":"Sommer","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine Medical Center\u2010University of Freiburg Faculty of Medicine University of Freiburg Freiburg Germany"},{"name":"Hermann Staudinger Graduate School University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Triebel","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine Medical Center\u2010University of Freiburg Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merja A.","family":"Neukamm","sequence":"additional","affiliation":[{"name":"Institute of Forensic Medicine Medical Center\u2010University of Freiburg Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Bode","sequence":"additional","affiliation":[{"name":"Heart Center Freiburg University Department of Cardiology and Angiology I Faculty of Medicine University of Freiburg Freiburg Germany"},{"name":"Department of Medicine III (Interdisciplinary Medical Intensive Care) Medical Center Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Supady","sequence":"additional","affiliation":[{"name":"Heart Center Freiburg University Department of Cardiology and Angiology I Faculty of Medicine University of Freiburg Freiburg Germany"},{"name":"Department of Medicine III (Interdisciplinary Medical Intensive Care) Medical Center Faculty of Medicine University of Freiburg Freiburg Germany"},{"name":"Heidelberg Institute of Global Health University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9107-5558","authenticated-orcid":false,"given":"Achim","family":"Lother","sequence":"additional","affiliation":[{"name":"Heart Center Freiburg University Department of Cardiology and Angiology I Faculty of Medicine University of Freiburg Freiburg Germany"},{"name":"Department of Medicine III (Interdisciplinary Medical Intensive Care) Medical Center Faculty of Medicine University of Freiburg Freiburg Germany"},{"name":"Institute of Experimental and Clinical Pharmacology and Toxicology Faculty of Medicine University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"National Institutes of Health COVID\u201019 Treatment Guidelines Panel. Coronavirus Disease 2019 (COVID\u201019) Treatment Guidelines.https:\/\/files.covid19treatmentguidelines.nih.gov\/guidelines\/section\/section_100.pdf. Accessed January 19 2021."},{"key":"e_1_2_11_3_1","unstructured":"Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID\u201019.https:\/\/www.idsociety.org\/globalassets\/idsa\/practice\u2010guidelines\/covid\u201019\/treatment\/idsa\u2010covid\u201019\u2010gl\u2010tx\u2010and\u2010mgmt\u2010v3.6.0.pdf. Accessed January 19 2021."},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03130-y"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-018-5464-6"},{"key":"e_1_2_11_6_1","unstructured":"United States Food and Drug Administration: CytoSorb\u00aeEmergency Use Authorization for Use in Patients with COVID\u201019 Infection.https:\/\/www.fda.gov\/media\/136866\/download. Accessed January 19 2021."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12840"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40635-020-00313-3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000063108"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1515\/cclm-2020-0612"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107940"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.705"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2019.06.078"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40268-020-00308-1"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000484923"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacbts.2017.01.007"}],"container-title":["Pharmacology Research &amp; Perspectives"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.743","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/prp2.743","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/prp2.743","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T04:30:55Z","timestamp":1693283455000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1002\/prp2.743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,12]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/prp2.743"],"URL":"https:\/\/doi.org\/10.1002\/prp2.743","archive":["Portico"],"relation":{},"ISSN":["2052-1707","2052-1707"],"issn-type":[{"value":"2052-1707","type":"print"},{"value":"2052-1707","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,12]]},"assertion":[{"value":"2021-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e00743"}}