{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T22:16:49Z","timestamp":1794003409897,"version":"4.8.0"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,3,15]],"date-time":"2021-03-15T00:00:00Z","timestamp":1615766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Postpartum hemorrhage (PPH) increases the risk of maternal death worldwide. Heat\u2010stable carbetocin, a long\u2010acting oxytocin analog, is a newer uterotonic agent. Clinicians do not fully understand its side\u2010effects, particularly the unanticipated side\u2010effects. The aim of this study is to investigate the side\u2010effects of carbetocin to PPH. The Cochrane Library, Web of Science, PubMed, Elsevier ScienceDirect, Embase, and ClinicalTrials.gov were searched from the inception to September 2020. Randomized controlled trials (RCTs) that considered pregnant women who received carbetocin before delivery and provided at least one adverse event were included. Statistical analysis included random or fixed\u2010effect meta\u2010analyses using relative risk. Stratified analyses and sensitivity analyses were also performed. Begger's and Egger's test and funnel plots were used to assess the publication bias. Seventeen RCTs involving 32,702 women were included, and all these studies ranked as medium\u2010 to high\u2010quality. Twenty\u2010four side\u2010effects were reported. The use of carbetocin had a lower risk of vomiting in intravenously (0.53, 0.30 to 0.93) and cesarean birth (0.51, 0.32 to 0.81) women, and had a slightly higher risk of diarrhea (8.00, 1.02 to 62.79) compared with oxytocin intervention. No significant difference was found among other side\u2010effects. Evidence from our systematic review and meta\u2010analysis of 17 RCTs suggested that the risk of vomiting decreased with carbetocin use in the prevention of PPH after delivery.<\/jats:p>","DOI":"10.1002\/prp2.745","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T06:48:17Z","timestamp":1615877297000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Side\u2010effects of carbetocin to prevent postpartum hemorrhage: A systematic review and meta\u2010analysis of randomized controlled trials"],"prefix":"10.1002","volume":"9","author":[{"given":"Wen","family":"Ai","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Foshan Chancheng Central Hospital Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Foshan Chancheng Central Hospital Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health Anhui Medical University Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Library the First Affiliated Hospital College of Medicine Zhejiang University Hangzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2773-9166","authenticated-orcid":false,"given":"Dazhi","family":"Fan","sequence":"additional","affiliation":[{"name":"Foshan Institute of Fetal Medicine Affiliated Foshan Maternity &amp; Child Healthcare Hospital Southern Medical University Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Integrated Traditional and Western Medicine Anhui University of Chinese Medicine Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Foshan Chancheng Central Hospital Foshan Guangdong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70227-X"},{"key":"e_1_2_11_3_1","volume-title":"WHO recommendations: Uterotonics for the prevention of postpartum haemorrhage","year":"2018"},{"key":"e_1_2_11_4_1","volume-title":"WHO Recommendations for the Prevention and Treatment of Postpartum Haemorrhage","year":"2012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.13998"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx1037"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv951"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.3082"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805489"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2018.04.002"},{"key":"e_1_2_11_11_1","first-page":"CD005457","article-title":"Carbetocin for preventing postpartum haemorrhage","volume":"4","author":"Su LL","year":"2012","journal-title":"The Cochrane Database Systematic Reviews"},{"key":"e_1_2_11_12_1","unstructured":"HigginsJPT SeG.Cochrane Handbook for Systematic Reviews of Interventions version 5.1.0 (updated March 2011). 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