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In this line, repurposing of existing drugs against known or predicted SARS\u2010CoV\u20102 protein actions have been advanced, while natural products have also been tested. Here, we propose that p\u2010cymene, a natural monoterpene, can act as a potential novel agent for the treatment of SARS\u2010CoV\u20102\u2010induced COVID\u201019 and other RNA\u2010virus\u2010induced diseases (influenza, rabies, Ebola). We show by extensive molecular simulations that SARS\u2010CoV\u20102 C\u2010terminal structured domain contains a nuclear localization signal (NLS), like SARS\u2010CoV, on which p\u2010cymene binds with low micromolar affinity, impairing nuclear translocation of this protein and inhibiting viral replication, as verified by preliminary <jats:italic>in vitro<\/jats:italic> experiments. A similar mechanism may occur in other RNA\u2010viruses (influenza, rabies and Ebola), also verified <jats:italic>in vitro<\/jats:italic> for influenza, by interaction of p\u2010cymene with viral nucleoproteins, and structural modification of their NLS site, weakening its interaction with importin A. This common mechanism of action renders therefore p\u2010cymene as a possible antiviral, alone, or in combination with other agents, in a broad spectrum of RNA viruses, from SARS\u2010CoV\u20102 to influenza A infections.<\/jats:p>","DOI":"10.1002\/prp2.798","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T06:37:01Z","timestamp":1623739021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["p\u2010cymene impairs SARS\u2010CoV\u20102 and Influenza A (H1N1) viral replication: <i>In silico<\/i> predicted interaction with SARS\u2010CoV\u20102 nucleocapsid protein and H1N1 nucleoprotein"],"prefix":"10.1002","volume":"9","author":[{"given":"Athanasios","family":"Panagiotopoulos","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Endocrinology School of Medicine University of Crete Heraklion 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