{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:07:25Z","timestamp":1753870045280,"version":"3.41.2"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T00:00:00Z","timestamp":1623628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In dialysis patients, cholesterol\u2010lowering therapy with statins is less effective than in other high\u2010risk patients. This may be explained by a shift from cholesterol synthesis toward cholesterol absorption. In line, markers of cholesterol absorption\u2014such as campesterol\u2014better predict atherosclerotic cardiovascular events than markers of cholesterol synthesis\u2014such as lathosterol\u2014in dialysis patients. To test the association between markers of cholesterol absorption such as campesterol\u2014and markers of cholesterol synthesis\u2014such as lathosterol\u2014against cardiovascular events in non\u2010dialysis CKD patients. Altogether 251 patients not on lipid\u2010lowering agents were followed annually for the composite endpoint atherosclerotic cardiovascular disease (ASCVD) and all\u2010cause death. During follow\u2010up of 5.2\u00a0\u00b1\u00a02.1\u00a0years, 61 participants reached the primary endpoint atherosclerotic cardiovascular disease\/all\u2010cause death [ASCVD\/D], 47 participants suffered from ASCVD, and 46 participants died. In univariate Cox regression analysis, campesterol\/lathosterol ratio did not significantly predict ASCVD\/D (HR 0.643; 0.358\u20131.155; 3rd vs. 1st tertile), all\u2010cause death (HR 1.309; 0.604\u20132.838; 3rd vs. 1st tertile) nor ASCVD (HR 0.589; 0.311\u20131.118; 3rd vs. 1st tertile). We did not observe a shift from cholesterol synthesis to cholesterol absorption across the spectrum of non\u2010dialysis CKD. Campesterol\/lathosterol ratio did not predict future ASCVD or all\u2010cause death in non\u2010dialysis CKD.<\/jats:p>","DOI":"10.1002\/prp2.801","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T06:35:12Z","timestamp":1623738912000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Markers of cholesterol synthesis to cholesterol absorption across the spectrum of non\u2010dialysis CKD: An observational study"],"prefix":"10.1002","volume":"9","author":[{"given":"Insa E.","family":"Emrich","sequence":"first","affiliation":[{"name":"Internal Medicine III \u2013 Cardiology, Angiology and Intensive Care Medicine Saarland University Medical Center Saarland University Homburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar H.","family":"Heine","sequence":"additional","affiliation":[{"name":"AGAPLESION MARKUS KRANKENHAUS Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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