{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:07:27Z","timestamp":1753870047889,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sevoflurane affects on the A1 receptor in the central nervous system and potentiates the action of neuromuscular blocking agents. In the present study, we investigated whether sevoflurane (SEVO) has the ability to potentiate the neuromuscular blocking effect of rocuronium and if the specific antagonist of adenosine receptor (SLV320) can reverse this effect. In this study, phrenic nerve\u2013hemidiaphragm tissue specimens were obtained from 40 Sprague\u2013Dawley (SD) rats. The specimens were immersed in an organ bath filled with Krebs buffer and stimulated by a train\u2010of\u2010four (TOF) pattern using indirect supramaximal stimulation at 20\u00a0s intervals. The specimens were randomly allocated to control, 2\u2010chloroadenosine (CADO), SEVO, or SLV320\u00a0+\u00a0SEVO groups. In the CADO and SLV320\u00a0+\u00a0SEVO groups, CADO and SLV320 were added to the organ bath from the start to a concentration of 10\u00a0\u03bcM and 10\u00a0nM, respectively. We then proceeded with rocuronium\u2010induced blockade of &gt;95% depression of the first twitch tension of TOF (T1) and TOF ratio (TOFR). In the SEVO and SLV320\u00a0+\u00a0SEVO groups, SEVO was added to the Krebs buffer solution to concentration of 400\u2013500\u00a0\u03bcM for 10\u00a0min. Sugammadex\u2010induced T1 and TOFR recovery was monitored for 30\u00a0min until &gt;95% of T1 and &gt;0.9 of TOFR were confirmed, and the recovery pattern was compared by plotting these data. T1 recovery in the SEVO and CADO groups was significantly delayed compared with the control and SLV320\u00a0+\u00a0SEVO groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). In conclusion, sevoflurane affects on the A1 receptor at the neuromuscular junction and delays sugammadex\u2010induced recovery from neuromuscular blockade.<\/jats:p>","DOI":"10.1002\/prp2.827","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T05:10:49Z","timestamp":1627881049000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of sevoflurane and adenosine receptor antagonist on the sugammadex\u2010induced recovery from rocuronium\u2010induced neuromuscular blockade in rodent phrenic nerve\u2013hemidiaphragm tissue specimens"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2369-6525","authenticated-orcid":false,"given":"Yong Beom","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine College of Medicine Gil Medical Center Gachon University Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Moon","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine Asan Medical Center Ulsan University, College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chungon","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine College of Medicine Gil Medical Center Gachon University Incheon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hey\u2010Ran","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Seoul Paik Hospital Inje University, College of Medicine Seoul Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junyong","family":"In","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Pain Medicine College of Medicine Ilsan Hospital Donggook University Goyang Gyeonggi Do Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010Seuk","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anaesthesiology and Pain Medicine Daejeon Eulji Hospital Eulji University Daejeon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0265021505001158"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.1973.tb07549.x"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199506000-00013"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0b013e3181c6be7e"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003643-200206000-00009"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2002.02020.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2011.05588.x"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2011.05476.x"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23346"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2013.08.004"},{"key":"e_1_2_9_12_1","first-page":"542","article-title":"Reversal of profound and \u201cdeep\u201d residual rocuronium\u2010induced neuromuscular blockade by sugammadex: a neurophysiological study","volume":"78","author":"Pavoni V","year":"2012","journal-title":"Minerva Anestesiol"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2013.65.6.501"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.4097\/kjae.2013.65.6.495"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.4097\/kja.d.17.00011"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-199506000-00008"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707319"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2044.1998.00278.x"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-540-89615-9_2"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.12220"},{"key":"e_1_2_9_21_1","first-page":"352","article-title":"Methylxanthines modulate adenosine release from slices of cerebral cortex","volume":"31","author":"Stone TW","year":"1981","journal-title":"Brain Res"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.003285"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.bja.a013380"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000539-199810000-00036"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0000000000000868"}],"container-title":["Pharmacology Research &amp; 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