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Nonetheless, hypomagnesemia should be suspected in clinical practice in patients with relevant symptomatology and also be considered a predisposing factor for the development of other electrolyte disturbances. Furthermore, chronic hypomagnesemia has been associated with diabetes mellitus and cardiovascular disease. Hypomagnesemia as a consequence of drug therapy is relatively common, with the list of drugs inducing low serum Mg levels expanding. Culprit medications linked to hypomagnesemia include antibiotics (e.g. aminoglycosides, amphotericin B), diuretics, antineoplastic drugs (cisplatin and cetuximab), calcineurin inhibitors, and proton pump inhibitors. In recent years, the mechanisms of drug\u2010induced hypomagnesemia have been unraveled through the discovery of key Mg transporters in the gut and kidney. This narrative review of available literature focuses on the pathogenetic mechanisms underlying drug\u2010induced hypomagnesemia in order to increase the insight of clinicians toward early diagnosis and effective management.<\/jats:p>","DOI":"10.1002\/prp2.829","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T04:26:16Z","timestamp":1626668776000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["An overview of diagnosis and management of drug\u2010induced hypomagnesemia"],"prefix":"10.1002","volume":"9","author":[{"given":"George","family":"Liamis","sequence":"first","affiliation":[{"name":"Department of Internal Medicine School of Medicine University of Ioannina Ioannina Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewout J.","family":"Hoorn","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Transplantation Department of 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