{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T10:00:37Z","timestamp":1777111237735,"version":"3.51.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>QTc interval prolongation is an adverse effect associated with the use of fluoroquinolones and macrolides. Ciprofloxacin and erythromycin are both frequently prescribed QTc\u2010prolonging drugs in critically ill patients. Critically ill patients may be more vulnerable to developing QTc prolongation, as several risk factors can be present at the same time. Therefore, it is important to know the QTc\u2010prolonging potential of these drugs in the intensive care unit (ICU) population. The aim of this study was to assess the dynamics of the QTc interval over a 24\u2010hour dose interval during intravenous ciprofloxacin and low\u2010dose erythromycin treatment. Therefore, an observational study was performed in ICU patients (\u226518\u00a0years) receiving ciprofloxacin 400\u00a0mg t.i.d. or erythromycin 100\u00a0mg b.i.d. intravenously. Continuous ECG data were collected from 2\u00a0h before to 24\u00a0h after the first administration. QT\u2010analyses were performed using high\u2010end holter software. The effect was determined with a two\u2010sample <jats:italic>t<\/jats:italic>\u2010test for clustered data on all QTc values. A linear mixed model by maximum likelihood was applied, for which QTc values were assessed for the available time intervals and therapy. No evident effect over time on therapy with ciprofloxacin and erythromycin was observed on QTc time. There was no significant difference (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.22) in QTc values between the ciprofloxacin group (mean 393\u00a0ms) and ciprofloxacin control group (mean 386\u00a0ms). The erythromycin group (mean 405\u00a0ms) and erythromycin control group (mean 404\u00a0ms) neither showed a significant difference (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.80). In 0.6% of the registrations (1.138 out of 198.270\u00a0samples) the duration of the QTc interval was longer than 500\u00a0ms. The index groups showed slightly more recorded QTc intervals over 500\u00a0ms. To conclude, this study could not identify differences in the QTc interval between the treatments analyzed.<\/jats:p>","DOI":"10.1002\/prp2.865","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T05:58:50Z","timestamp":1635227930000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dynamics of the QTc interval over a 24\u2010h dose interval after start of intravenous ciprofloxacin or low\u2010dose erythromycin administration in ICU patients"],"prefix":"10.1002","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2723-8919","authenticated-orcid":false,"given":"Florine A.","family":"Berger","sequence":"first","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus MC, University Medical Center Rotterdam Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2667-3169","authenticated-orcid":false,"given":"Willem","family":"van Weteringen","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Erasmus MC Sophia Children\u2019s Hospital, University Medical Center Rotterdam Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1744-0999","authenticated-orcid":false,"given":"Heleen","family":"van der Sijs","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus MC, University Medical Center Rotterdam Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6856-7028","authenticated-orcid":false,"given":"Nicole G. M.","family":"Hunfeld","sequence":"additional","affiliation":[{"name":"Department of Hospital Pharmacy Erasmus MC, University Medical Center Rotterdam Rotterdam the Netherlands"},{"name":"Department of Intensive Care Erasmus MC, University Medical Center Rotterdam Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7897-4628","authenticated-orcid":false,"given":"Jeroen J. H.","family":"Bunge","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Erasmus MC, University Medical Center Rotterdam Rotterdam the Netherlands"},{"name":"Department of Cardiology Erasmus MC, University Medical Center Rotterdam Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0259-6691","authenticated-orcid":false,"given":"Natasja M. 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