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This is because ACE2\u00a0limits the production of the peptide angiotensin II (Ang II) and SARS\u2010CoV\u20102, through the destruction of ACE2, allows the uncontrolled production of Ang II. Recovery from trauma requires activation of both a tissue response to injury and activation of a whole\u2010body response to maintain tissue perfusion. Tissue and circulating renin\u2010angiotensin systems (RASs) play an essential role in the host response to infection and injury because of the actions of Ang II, mediated via its AT<jats:sub>1<\/jats:sub> receptor. Both tissue and circulating arms of the renin angiotensin aldosterone system's (RAAS) response to injury need to be regulated. The effects of Ang II and the steroid hormone, aldosterone, on fluid and electrolyte homeostasis and on the circulation are controlled by elaborate feedback networks that respond to alterations in the composition and volume of fluids within the circulatory system. The role of Ang II in the tissue response to injury is however, controlled mainly by its metabolism and conversion to Ang\u2010(1\u20107) by the enzyme ACE2. Ang\u2010(1\u20107) has effects that are contrary to Ang II\u2010AT<jats:sub>1<\/jats:sub>R mediated effects. Thus, destruction of ACE2 by SARS\u2010CoV\u20102 results in loss of control of the pro\u2010inflammatory actions of Ang II and tissue destruction. 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