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Such therapies are mainly performed by injection of antibodies against cytokines or cytokine receptors. We initially found that the glycolytic inhibitor 2\u2010deoxy\u2010<jats:sc>d<\/jats:sc>\u2010glucose (2\u2010DG), a simple monosaccharide, attenuated cellular responses to IL\u20106 by inhibiting N\u2010linked glycosylation of the IL\u20106 receptor gp130. Aglycoforms of gp130 did not bind to IL\u20106 or activate downstream intracellular signals that included Janus kinases. 2\u2010DG completely inhibited dextran sodium sulfate\u2010induced colitis, a mouse model for inflammatory bowel disease, and alleviated laminarin\u2010induced arthritis in the SKG mouse, an experimental model for human rheumatoid arthritis. These diseases have been shown to be partially dependent on IL\u20106. We also found that 2\u2010DG inhibited signals for other proinflammatory cytokines such as TNF\u2010\u03b1, IL\u20101\u03b2, and interferon \u2010\u03b3, and accordingly, prevented death by another inflammatory disease, lipopolysaccharide (LPS) shock. Furthermore, 2\u2010DG prevented LPS shock, a model for a cytokine storm, and LPS\u2010induced pulmonary inflammation, a model for acute respiratory distress syndrome of coronavirus disease 2019 (COVID\u201019). 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