{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:47:40Z","timestamp":1791978460203,"version":"4.4.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:00:00Z","timestamp":1650758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2022,4,24]],"date-time":"2022-04-24T00:00:00Z","timestamp":1650758400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Monocarboxylate transporter 6 (MCT6;\n                    <jats:italic>SLC16A5<\/jats:italic>\n                    ) is an orphan transporter protein with expression in multiple tissues. The endogenous function of MCT6 related to human health and disease remains unknown. Our previous transcriptomic and proteomic analyses in Mct6\u00a0knockout (KO) mice suggested that MCT6\u00a0may play a role in lipid and glucose homeostasis, but additional evidence is required. Thus, the objective of this study was to further explore the impact of MCT6 on metabolic function using untargeted metabolomic analysis in Mct6\u00a0KO mice. The plasma from male and female mice and livers from male mice were submitted for global metabolomics analysis to assess the relative changes in endogenous small molecules across the liver and systemic circulation associated with absence of Mct6. More than 782 compounds were detected with 101 and 51\u00a0metabolites significantly changed in plasma of male and female mice, respectively, and 100\u00a0metabolites significantly changed in the livers of male mice (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a0.05). Significant perturbations in lipid metabolism were annotated in the plasma and liver metabolome, with additional alterations in the amino acid metabolism pathway in plasma samples from male and female mice. Elevated lipid diacylglycerol and altered fatty acid metabolite concentrations were found in liver and plasma samples of male Mct6\u00a0KO mice. Significant reduction of N\u2010terminal acetylated amino acids was found in plasma samples of male and female Mct6\u00a0KO mice. In summary, the present study confirmed the significant role of MCT6 in lipid and amino acid homeostasis, suggesting its contribution in metabolic diseases.\n                  <\/jats:p>","DOI":"10.1002\/prp2.944","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:24:27Z","timestamp":1650846267000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Untargeted metabolomics identifies the potential role of monocarboxylate transporter 6 (MCT6\/\n                    <i>SLC16A5<\/i>\n                    ) in lipid and amino acid metabolism pathways"],"prefix":"10.1002","volume":"10","author":[{"given":"Tianjing","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical Sciences University at Buffalo State University of New York  Buffalo New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert S.","family":"Jones","sequence":"additional","affiliation":[{"name":"Drug Metabolism and Pharmacokinetics Genentech, Inc.  South San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1127-7964","authenticated-orcid":false,"given":"Marilyn E.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences School of Pharmacy and Pharmaceutical Sciences University at Buffalo State University of New York  Buffalo New York 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