{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T21:39:52Z","timestamp":1763415592226,"version":"3.41.2"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T00:00:00Z","timestamp":1658880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31340064"],"award-info":[{"award-number":["31340064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pharmacology Res &amp; Perspec"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The relationship between cardiovascular diseases and iron disorders has gained increasing attention; however, the effects of hypotensive drugs on iron metabolic alterations in hypertension are not well understood. The purpose of this study was to investigate iron metabolic changes after prazosin treatment of spontaneously hypertensive rats (SHRs) and Wistar\u2013Kyoto (WKY) rats. Our second objective was to examine the effects of hypertension and anti\u2010hypertensive drugs on bone formation and resorption. SHRs and WKY rats were randomized into either prazosin\u2010treated groups (WKY\u2009+\u2009PZ and SHR\u2009+\u2009PZ) or untreated groups (WKY and SHR). After 7\u2009days of intragastric prazosin administration, the rats were sacrificed for analysis; blood samples and organs (the duodenum, liver, kidneys, spleen, and femur) were collected. Both WKY\u2009+\u2009PZ and SHR groups exhibited iron deficiency in the serum and liver. Prazosin increased the iron levels in the bone tissue of SHRs. Prazosin stimulated the expression of hepcidin mRNA in the liver of SHRs and inhibited the expression of this iron\u2010regulatory hormone in WKY rats. FPN1 expression in the duodenum was increased significantly in SHRs, however markedly decreased after prazosin treatment. The expression of TLR4 and Ctsk was enhanced in the bone tissue of SHRs, whereas CLC\u20107 expression was inhibited. Both hypotension and hypertension can lead to iron deficiency. Treatment with prazosin restored iron homeostasis in SHRs. The inverse impacts of prazosin on hepatic hepcidin expression in SHRs versus WKY rats indicates differing iron regulatory mechanisms between hypertensive and normal animals. The osteoclast activity was found to be enhanced in SHRs. Further study is needed to address whether the changes in osteoblast and osteoclast activity in SHRs correlates with the effects on iron metabolism.<\/jats:p>","DOI":"10.1002\/prp2.991","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T07:55:21Z","timestamp":1658908521000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Influence of prazosin on systemic iron levels and the associated iron metabolic alterations in spontaneously hypertensive rats"],"prefix":"10.1002","volume":"10","author":[{"given":"Hengrui","family":"Chang","sequence":"first","affiliation":[{"name":"Department of Spinal Surgery The Third Hospital of Hebei Medical University  Shijiazhuang Hebei People's Republic of China"},{"name":"College of Life Science Hebei Normal University  Shijiazhuang Hebei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Science Hebei Normal University  Shijiazhuang Hebei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Xin","sequence":"additional","affiliation":[{"name":"College of Life Science Hebei Normal University  Shijiazhuang Hebei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Science Hebei Normal University  Shijiazhuang Hebei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyuan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Spinal Surgery The Third Hospital of Hebei Medical University  Shijiazhuang Hebei People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6386-9649","authenticated-orcid":false,"given":"Yan\u2010Zhong","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Life Science Hebei Normal University  Shijiazhuang Hebei People's Republic of 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