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During analysis of aged quality\u2010control samples, a previously unreported chromatographic response was observed at a shorter retention time than PPZHCl. Further investigation of formulations stored in trap tap devices at temperatures ranging from 5 to 40 \u00b0C during field trials at four different locations confirmed the degradation of the active ingredient. Further investigation using HPLC\/tandem mass spectrometry revealed two to five degradates, with the major degradates being oxidation products of the active ingredient, PPZHCl. As PPZHCl formulations must be stable when stored at 5 to 40 \u00b0C for 6 to 12 months, reformulation with the anti\u2010oxidant ascorbic acid was utilized to achieve the required PPZHCl stability. Copyright \u00a9 2005 Society of Chemical Industry<\/jats:p>","DOI":"10.1002\/ps.1018","type":"journal-article","created":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T06:19:13Z","timestamp":1106633953000},"page":"605-611","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Stability of the tranquilizer drug propionylpromazine hydrochloride in formulated products"],"prefix":"10.1002","volume":"61","author":[{"given":"Thomas M","family":"Primus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce A","family":"Kimball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerome","family":"Hurley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John J","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherm","family":"Blom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J","family":"Savarie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,1,25]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)94231-6"},{"key":"e_1_2_6_3_2","first-page":"922","article-title":"Distribution of combelene and combelene sulphoxide residues in the pig","volume":"66","author":"Arneth W","year":"1986","journal-title":"Fleischwirtschaft"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2885.1981.tb00865.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9673(00)94567-9"},{"key":"e_1_2_6_6_2","first-page":"175","article-title":"Injuries to coyotes and other species caused by four models of footholding devices","volume":"18","author":"Onderka DK","year":"1990","journal-title":"Wildl Soc Bull"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.2307\/3798040"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1520\/STP34983S"},{"key":"e_1_2_6_9_2","first-page":"1560","article-title":"The steel leg\u2010hold trap: techniques for reducing foot injury and increasing selectivity","volume":"3","author":"Linhart SB","year":"1981","journal-title":"Proc Worldwide Furbearer Conf"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/jaoac\/82.6.1321","article-title":"Determination of propionylpromazine hydrochloride in formulation matrixes using reversed\u2010phase ion\u2010pair small bore liquid chromatography","volume":"82","author":"Hurlbut DB","year":"1999","journal-title":"J AOAC Int"}],"container-title":["Pest Management Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fps.1018","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ps.1018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:32:13Z","timestamp":1761057133000},"score":1,"resource":{"primary":{"URL":"https:\/\/scijournals.onlinelibrary.wiley.com\/doi\/10.1002\/ps.1018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1,25]]},"references-count":9,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1002\/ps.1018"],"URL":"https:\/\/doi.org\/10.1002\/ps.1018","archive":["Portico"],"relation":{},"ISSN":["1526-498X","1526-4998"],"issn-type":[{"type":"print","value":"1526-498X"},{"type":"electronic","value":"1526-4998"}],"subject":[],"published":{"date-parts":[[2005,1,25]]},"assertion":[{"value":"2004-06-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2004-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2005-01-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}