{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T01:37:23Z","timestamp":1789349843854,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2005,6,13]],"date-time":"2005-06-13T00:00:00Z","timestamp":1118620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The effects of diverse phenylaminopyrimidines (PAP), namely PAP\u2010pyridines (type A), PAP\u2010pyrazoles (type B) and PAP\u2010thiazoles (type C), on\n                    <jats:italic>Neurospora crassa<\/jats:italic>\n                    Shear &amp; Dodge has been investigated. The results revealed that type A strongly inhibit the\n                    <jats:italic>in vitro<\/jats:italic>\n                    growth of\n                    <jats:italic>N crassa<\/jats:italic>\n                    , whereas types B and C are much less active. A significant correlation was observed between the\n                    <jats:italic>Neurospora<\/jats:italic>\n                    growth inhibition and the intrinsic activity of type A compounds on the cyclin\u2010dependent protein kinase p34\n                    <jats:sup>CDC2<\/jats:sup>\n                    of starfish, suggesting that the target of phenylaminopyrimidines in fungi is a cyclin\u2010dependent protein kinase (CDK). The phenylaminopyrimidine\u2010binding CDKs Phoss (major band) and CDC2 (minor band) involved in phosphorus uptake, glycogen synthesis and the cell cycle were identified from\n                    <jats:italic>N crassa<\/jats:italic>\n                    by affinity chromatography on phenylaminopyrimidine\u2013sepharose. Comparative experiments with different protein kinases revealed the importance of the side chain of phenylaminopyrimidines for their target selectivity. A type B compound was found to selectively inhibit the MAP\u2010kinase OS\u20102 involved in the osmoregulatory pathway of\n                    <jats:italic>Neurospora<\/jats:italic>\n                    . Copyright \u00a9 2005 Society of Chemical Industry\n                  <\/jats:p>","DOI":"10.1002\/ps.1080","type":"journal-article","created":{"date-parts":[[2005,6,13]],"date-time":"2005-06-13T07:17:33Z","timestamp":1118647053000},"page":"1069-1076","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Evaluation of phenylaminopyrimidines as antifungal protein kinase inhibitors"],"prefix":"10.1002","volume":"61","author":[{"given":"Christian","family":"Pillonel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,6,13]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9063(199703)49:3<229::AID-PS525>3.0.CO;2-T"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ps.2780360312"},{"key":"e_1_2_6_4_2","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1128\/aem.61.6.2341-2345.1995","article-title":"A serine (threonine) protein kinase confers fungicide resistance in the phytopathogenic fungus Ustilago maydis","volume":"61","author":"Orth AB","year":"1995","journal-title":"Appl Environ Microbiol"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1094\/PHYTO.2002.92.1.75"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.68.2.532-538.2002"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1128\/MMBR.62.2.249-274.1998","article-title":"Signalling in the yeasts: an informational cascade with links to the filamentous fungi","volume":"62","author":"Banuett F","year":"1998","journal-title":"Microb Molec Biol Rev"},{"key":"e_1_2_6_8_2","doi-asserted-by":"crossref","unstructured":"XuJ\u2010R MAP kinases in fungal pathogens.Fungal Genetics and Biology.http:\/\/www.idealibrary.com1\u201316 (2000).","DOI":"10.1006\/fgbi.2000.1237"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.13.1.261"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008115004986"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568011033353605"},{"key":"e_1_2_6_12_2","unstructured":"EberleM StierliD PillonelChandZieglerH N\u2010phenyl\u20104\u2010(4\u2010pyridyl)\u20102\u2010pyrimidinamine derivatives as antimicrobials and nematocides for plant protection. 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