{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:49:05Z","timestamp":1791208145911,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,10,29]],"date-time":"2012-10-29T00:00:00Z","timestamp":1351468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2013,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>BACKGROUND: Anticoagulants are the only available compounds in the EU to control rat populations. Resistance to anticoagulant rodenticides (antivitamin K or AVK) is described and widespread across Europe. The present objective was to determine whether resistance was associated with an increased potential for bioaccumulation of AVK in the liver. Rats were selected from three major resistant genetically identified strains across Europe: Y139C (Germany), Y139F (France) and L120Q (United Kingdom). The rats were housed in individual cages and fed chlorophacinone wheat bait (50 mg kg<jats:sup>\u22121<\/jats:sup>). Animals were assigned to groups for euthanasia either on day 1, 4, 9 or 14 (resistant rats) or on days 1 and 4 (susceptible rats).<\/jats:bold><\/jats:p><jats:p><jats:bold>RESULTS: Chlorophacinone accumulated from day 1 to day 4 in all strains (maximum 160 \u00b5g liver<jats:sup>\u22121<\/jats:sup>) and remained stable thereafter. There was no significant difference between strains. Extensive metabolism of chlorophacinone was also found, and was similar (in nature and proportion of metabolites) across strains (3 OH\u2010metabolites identified). Only the survival time differed significantly (L120Q &gt; Y139C = Y139F &gt; susceptible).<\/jats:bold><\/jats:p><jats:p><jats:bold>CONCLUSIONS: Accumulation of chlorophacinone occurs from day 1 to day 4, and an equilibrium is reached, suggesting rapid elimination. Resistant and susceptible rats accumulate chlorophacinone to the same extent and only differ in terms of survival times. Resistant rats may then be a threat for non\u2010target species for prolonged periods of time. \u00a9 2012 Society of Chemical Industry<\/jats:bold><\/jats:p>","DOI":"10.1002\/ps.3367","type":"journal-article","created":{"date-parts":[[2012,5,23]],"date-time":"2012-05-23T12:20:39Z","timestamp":1337775639000},"page":"397-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Bioaccumulation of chlorophacinone in strains of rats resistant to anticoagulants"],"prefix":"10.1002","volume":"69","author":[{"given":"Julie","family":"Vein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dani\u00e8le","family":"Vey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Fourel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Berny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,10,29]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"611","article-title":"Rodent resistance to the anticoagulant rodenticides, with particular reference to Denmark","volume":"47","author":"Lund M","year":"1972","journal-title":"Bull WHO"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400026760"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022172400070820"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","unstructured":"BernyP Challenges of anticoagulant rodenticides: resistance and ecotoxicology.Pesticides in the Modern World\u2014Pest Control and Pesticides Exposure and Toxicity Assessment ed. by M. Stoytcheva. [Online]. InTech. Available:http:\/\/www.intechopen.com\/articles\/show\/title\/challenges-of-anticoagulant-rodenticides-resistance-and-ecotoxicology Pesticides in the Modern World-Pests Control and Pesticides Exposure and Toxicity Assessment ISBN: 978-953-307-457-3 DOI: 10.5772\/19916[].","DOI":"10.5772\/19916"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0045-6535(97)00242-7"},{"key":"e_1_2_7_7_1","unstructured":"EricksonWandUrbanD Potential risk of nine rodenticides to birds and nontarget mammals: a comparative approach. 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