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In a continuous effort to discover new maleimides with good antifungal activities, the authors have synthesised a series of 3,4\u2010dichloro\u2010, 3\u2010methyl and non\u2010substituted maleimides based on previous studies. The compounds were biologically evaluated against the fungal pathogen <jats:italic>Sclerotinia sclorotiorum.<\/jats:italic><\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of the 63 compounds evaluated, 25 compounds had interesting inhibitory potency with <jats:styled-content style=\"fixed-case\">EC<jats:sub>50<\/jats:sub><\/jats:styled-content> &lt; 10 \u00b5g <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>. <jats:italic>N<\/jats:italic>\u2010(3,5\u2010Dichlorophenyl)\u20103,4\u2010dichloromaleimide (<jats:styled-content style=\"fixed-case\">EC<jats:sub>50<\/jats:sub><\/jats:styled-content> = 1.11 \u00b5g <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>) and <jats:italic>N<\/jats:italic>\u2010octyl\u20103\u2010methylmaleimide (<jats:styled-content style=\"fixed-case\">EC<jats:sub>50<\/jats:sub><\/jats:styled-content> = 1.01 \u00b5g <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>) were more potent than the commercial fungicide dicloran (<jats:styled-content style=\"fixed-case\">EC<jats:sub>50<\/jats:sub><\/jats:styled-content> = 1.72 \u00b5g <jats:styled-content style=\"fixed-case\">mL<\/jats:styled-content><jats:sup>\u22121<\/jats:sup>). The results showed that compounds exhibiting log <jats:italic>P<\/jats:italic> values within the range 2.4\u20133.0 displayed the best results in terms of fungicidal activity, and this seemed, therefore, to be the optimum range for this physicochemical parameter.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The present work demonstrates that some maleimides can be used as potential lead compounds for developing novel antifungal agents against <jats:italic>S. sclerotiorum<\/jats:italic>. \u00a9 2014 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.3824","type":"journal-article","created":{"date-parts":[[2014,5,5]],"date-time":"2014-05-05T15:44:57Z","timestamp":1399304697000},"page":"433-440","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Synthesis and antifungal evaluation of a series of maleimides"],"prefix":"10.1002","volume":"71","author":[{"given":"Xiao\u2010Long","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Fermentation Engineering, College of Biological and Environmental Engineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010Jun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Fermentation Engineering, College of Biological and Environmental Engineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu\u2010Ge","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Fermentation Engineering, College of Biological and Environmental Engineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong\u2010Xian","family":"Fan","sequence":"additional","affiliation":[{"name":"Institute of Fermentation Engineering, College of Biological and Environmental Engineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Vegetables and Flowers Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bao\u2010Ju","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Vegetables and Flowers Chinese Academy of Agricultural Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin\u2010Chu","family":"Shen","sequence":"additional","affiliation":[{"name":"Institute of Fermentation Engineering, College of Biological and Environmental Engineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1094\/Phyto-69-875"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2011.55"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fcr.2011.11.022"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10327-007-0004-1"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02981475"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02980520"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf050697d"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1071\/AP08087"},{"key":"e_1_2_6_10_1","first-page":"165","article-title":"Benefits and problems of fungicide control of Botrytis cinerea in vineyards of Champagne","volume":"42","author":"Couderchet M","year":"2003","journal-title":"Vitis"},{"key":"e_1_2_6_11_1","first-page":"56","article-title":"Mutation in b\u2010tubulin of Sclerotinia sclerotiorum conferring resistance to carbendazim in rapeseed field isolate","volume":"25","author":"Li HX","year":"2003","journal-title":"Chin J Oil Crop Sci"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1094\/PDIS-93-1-0036"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2012.04.004"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr050029r"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1071\/CH04273"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja909150y"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/np070634k"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1584\/jpestics.D11-054"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201000369"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2010.34"},{"key":"e_1_2_6_21_1","unstructured":"KawadaS MachiK Ito H Matsui K and Kasugai H Novel maleimide and agricultural fungicide. 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