{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:52:11Z","timestamp":1790283131194,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,13]],"date-time":"2015-05-13T00:00:00Z","timestamp":1431475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>After reports of management problems in practice, a survey was conducted to determine the presence of bromadiolone\u2010resistant animals in different house mouse (<jats:italic>Mus musculus<\/jats:italic> L.) populations in Serbia. A 21 day no\u2010choice feeding test was carried out to examine the resistance of house mice to bromadiolone. Eighty house mice collected from four locations (ten males and ten females per location) were tested for bromadiolone tolerance. Surviving animals and their <jats:styled-content style=\"fixed-case\">F<jats:sub>1<\/jats:sub><\/jats:styled-content> offspring were screened for mutations. The influence of <jats:styled-content style=\"fixed-case\">VKOR<\/jats:styled-content> variant, zygosity and sex on bromadiolone tolerance was analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Bait intake and changes in body weight revealed different animal responses regarding susceptibility or resistance. <jats:styled-content style=\"fixed-case\">Leu128Ser<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">Tyr139Cys<\/jats:styled-content> and a new <jats:styled-content style=\"fixed-case\">Ala21Thr<\/jats:styled-content> polymorphism were detected in wild\u2010born survivors and their <jats:styled-content style=\"fixed-case\">F<jats:sub>1<\/jats:sub><\/jats:styled-content> generation. However, not every individual with the polymorphisms <jats:styled-content style=\"fixed-case\">Leu128Ser<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">Tyr139Cys<\/jats:styled-content> survived the feeding test. <jats:styled-content style=\"fixed-case\">VKOR<\/jats:styled-content> variants and sex caused variations in bromadiolone tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>For the first time it was shown that the <jats:styled-content style=\"fixed-case\">VKOR<\/jats:styled-content> variant, along with sex, is responsible for bromadiolone tolerance in house mice. Other factors influencing bromadiolone tolerance, including sex\u2010specific factors, cannot be excluded. The tolerance levels of <jats:styled-content style=\"fixed-case\">VKOR<\/jats:styled-content> variants should be determined in further studies in order to evaluate the effectiveness of bromadiolone in sustainable management. \u00a9 2015 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.4027","type":"journal-article","created":{"date-parts":[[2015,4,22]],"date-time":"2015-04-22T06:10:05Z","timestamp":1429683005000},"page":"574-579","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["<scp>VKOR<\/scp> variant and sex are the main influencing factors on bromadiolone tolerance of the house mouse (<i>Mus musculus<\/i> L.)"],"prefix":"10.1002","volume":"72","author":[{"given":"Tanja","family":"\u0160\u0107epovi\u0107","sequence":"first","affiliation":[{"name":"Institute of Pesticides and Environmental Protection  Zemun Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Goran","family":"Joki\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pesticides and Environmental Protection  Zemun Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Esther","sequence":"additional","affiliation":[{"name":"Vertebrate Research, Institute for Plant Protection in Horticulture and Forestry Julius K\u00fchn Institute, Federal Research Institute for Cultivated Plants  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dragan","family":"Kataranovski","sequence":"additional","affiliation":[{"name":"Department of Ecology Institute for Biological Research \u2018Sinisa Stankovic\u2019, University of Belgrade  Belgrade Serbia"},{"name":"Institute of Zoology, Faculty of Biology University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petar","family":"Vuk\u0161a","sequence":"additional","affiliation":[{"name":"Institute for Phytopharmacy, Faculty of Agriculture University of Belgrade  Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana","family":"\u0110edovi\u0107","sequence":"additional","affiliation":[{"name":"Institute of Pesticides and Environmental Protection  Zemun Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Vuk\u0161a","sequence":"additional","affiliation":[{"name":"Institute of Pesticides and Environmental Protection  Zemun Belgrade Serbia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,13]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"1","volume-title":"Vertebrate Pests Post\u2010harvest Operations","author":"Brooks JE","year":"1999"},{"key":"e_1_2_7_3_1","first-page":"48","volume-title":"Human Conflicts with Wildlife: Economic Considerations. 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