{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T18:12:40Z","timestamp":1778695960924,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,22]],"date-time":"2015-05-22T00:00:00Z","timestamp":1432252800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Faced with the need to develop herbicides with different modes of action on account of weed resistance to existing herbicides, the sesquiterpene lactones can be the starting point in the search for new bioactive compounds. Lumisantonin and five novel amides have been evaluated against two monocotyledons and three dicotyledons.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>An efficient and versatile synthesis of lumisantonin and the five novel amides has been accomplished from readily available <jats:italic>\u03b1<\/jats:italic>\u2010santonin. These compounds were subjected to evaluation for their biological activity against <jats:italic>Sorghum bicolor<\/jats:italic> (sorghum), <jats:italic>Allium cepa<\/jats:italic> (onion), <jats:italic>Cucumis sativus<\/jats:italic> (cucumber), <jats:italic>Solanum lycopersicum<\/jats:italic> (tomato) and <jats:italic>Bidens pilosa<\/jats:italic> (beggartick). Lumisantonin has inhibited the development of the aerial parts of sorghum and onion by 76 and 67% at 1000 <jats:styled-content style=\"fixed-case\">\u00b5M<\/jats:styled-content> respectively. One of the novel amides has prevented the growth of shoots and radicles of sorghum by 80 and 71% at 1000 <jats:styled-content style=\"fixed-case\">\u00b5M<\/jats:styled-content> respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>All of the tested compounds have been found to exhibit promising seed germination inhibition. We can conclude that lumisantonin was on average the most lethal against all plant species evaluated; however, two of the novel amides have exhibited inhibition selectivity against monocotyledons when compared with dicotyledons. \u00a9 2015 Society of Chemical Industry<\/jats:p><\/jats:sec>","DOI":"10.1002\/ps.4028","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T03:41:52Z","timestamp":1429846912000},"page":"580-584","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Novel platensimycin derivatives with herbicidal activity"],"prefix":"10.1002","volume":"72","author":[{"given":"Fernanda C","family":"Moraes","sequence":"first","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Vi\u00e7osa  Vi\u00e7osa MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elson S","family":"Alvarenga","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Vi\u00e7osa  Vi\u00e7osa MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kariny B","family":"Amorim","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Vi\u00e7osa  Vi\u00e7osa MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio J","family":"Demuner","sequence":"additional","affiliation":[{"name":"Departamento de Qu\u00edmica Universidade Federal de Vi\u00e7osa  Vi\u00e7osa MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milton E","family":"Pereira\u2010Flores","sequence":"additional","affiliation":[{"name":"Departamento de Engenharia Agr\u00edcola e Ambiental Universidade Federal de Vi\u00e7osa  Vi\u00e7osa MG Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,5,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2013.03.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/np2009913"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/np300639b"},{"key":"e_1_2_7_5_1","first-page":"167","article-title":"Guaianolides for multipurpose molecular design. 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