{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T17:03:38Z","timestamp":1788282218116,"version":"build-2803163510"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY16C140007"],"award-info":[{"award-number":["LY16C140007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21002090"],"award-info":[{"award-number":["21002090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Aedes aegypti<\/jats:italic>\n                      is a major mosquito vector for the transmission of serious diseases, especially dengue and yellow fever. More than 1 billion people in developing countries are at risk. The widespread and continual use of pesticides can lead to resistant mosquitoes. In order to maintain mosquito control gains, it is critical to develop and evaluate novel bioactive molecules that differ in mode of action from currently used products.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A series of novel pyrimidine derivatives were designed and synthesized. Their structures were elucidated by proton nuclear magnetic resonance spectroscopy and high\u2010resolution mass spectrometry. The biological activities of these compounds were tested against\n                      <jats:italic>Ae. aegypti<\/jats:italic>\n                      . Many of them exhibited insecticidal activity against adult and larval mosquitoes. Compound 4d displayed relatively good activity to reach 70% mortality at 2 \u00b5g mL\n                      <jats:sup>\u22121<\/jats:sup>\n                      . Furthermore, density functional theory calculations were established to study the structure\u2013activity relationship of these novel compounds.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>CONCLUSION<\/jats:title>\n                    <jats:p>A practical synthetic route for pyrimidine derivatives is presented. This study suggests that these pyrimidine derivatives exhibit some activity against the yellow fever mosquito and, with further structure modification, could be novel lead compounds for the development of insecticides against mosquitoes. \u00a9 2016 Society of Chemical Industry<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ps.4370","type":"journal-article","created":{"date-parts":[[2016,7,23]],"date-time":"2016-07-23T04:16:39Z","timestamp":1469247399000},"page":"953-959","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Synthesis and insecticidal activity of novel pyrimidine derivatives containing urea pharmacophore against\n                    <i>Aedes aegypti<\/i>"],"prefix":"10.1002","volume":"73","author":[{"given":"Xing\u2010Hai","family":"Liu","sequence":"first","affiliation":[{"name":"College of Chemical Engineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao\u2010Hui","family":"Sun","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E","family":"Wedge","sequence":"additional","affiliation":[{"name":"USDA\u2010ARS Natural Products Utilization Research Unit  University MS USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James J","family":"Becnel","sequence":"additional","affiliation":[{"name":"USDA\u2010ARS, Center for Medical Agricultural and Veterinary Entomology (CMAVE)  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alden S","family":"Estep","sequence":"additional","affiliation":[{"name":"Navy Entomology Center of Excellence CMAVE Detachment  Gainesville FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng\u2010Xia","family":"Tan","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Quan","family":"Weng","sequence":"additional","affiliation":[{"name":"College of Chemical Engineering Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0966-842X(01)02288-0"},{"key":"e_1_2_5_3_1","first-page":"S98","article-title":"Emerging flaviviruses: the spread and resurgence of Japanese encephalitis","volume":"10","author":"Mackenzie JS","year":"2004","journal-title":"West Nile and dengue viruses. 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US Patent 8389718 Vestaron Corporation (2013)."},{"key":"e_1_2_5_25_1","unstructured":"WoodWW FlemingLandCucciaSJ Use of aryl\u2010substituted pyrimidines as insecticidal and acaricidal agents. 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