{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T10:48:02Z","timestamp":1790246882380,"version":"4.1.0"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,12,17]],"date-time":"2016-12-17T00:00:00Z","timestamp":1481932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["scijournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Pest Management Science"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Natural products (<jats:styled-content style=\"fixed-case\">NPs<\/jats:styled-content>) have a long history as a source of, and inspiration for, novel agrochemicals. Many of the existing herbicides, fungicides, and insecticides have their origins in a wide range of <jats:styled-content style=\"fixed-case\">NPs<\/jats:styled-content> from a variety of sources. Owing to the changing needs of agriculture, shifts in pest spectrum, development of resistance, and evolving regulatory requirements, the need for new agrochemical tools remains as critical as ever. As such, <jats:styled-content style=\"fixed-case\">NPs<\/jats:styled-content> continue to be an important source of models and templates for the development of new agrochemicals, demonstrated by the fact that <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> models exist for many of the pest control agents that were discovered by other means. Interestingly, there appear to be distinct differences in the success of different <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> sources for different pesticide uses. Although a few microbial <jats:styled-content style=\"fixed-case\">NPs<\/jats:styled-content> have been important starting points in recent discoveries of some insecticidal agrochemicals, historically plant sources have contributed the most to the discovery of new insecticides. In contrast, fungi have been the most important <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> sources for new fungicides. Like insecticides, plant\u2010sourced <jats:styled-content style=\"fixed-case\">NPs<\/jats:styled-content> have made the largest contribution to herbicide discovery. Available data on 2014 global sales and numbers of compounds in each class of pesticides indicate that the overall impact of <jats:styled-content style=\"fixed-case\">NPs<\/jats:styled-content> to the discovery of herbicides has been relatively modest compared to the impact observed for fungicides and insecticides. However, as new sourcing and approaches to <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content> discovery evolve, the impact of <jats:styled-content style=\"fixed-case\">NPs<\/jats:styled-content> in all agrochemical arenas will continue to expand. \u00a9 2016 Society of Chemical Industry<\/jats:p>","DOI":"10.1002\/ps.4458","type":"journal-article","created":{"date-parts":[[2016,10,14]],"date-time":"2016-10-14T01:42:50Z","timestamp":1476409370000},"page":"700-715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":210,"title":["Natural products, their derivatives, mimics and synthetic equivalents: role in agrochemical discovery"],"prefix":"10.1002","volume":"73","author":[{"given":"Thomas C","family":"Sparks","sequence":"first","affiliation":[{"name":"Dow AgroSciences Discovery Research  Indianapolis IN 46268 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald R","family":"Hahn","sequence":"additional","affiliation":[{"name":"Dow AgroSciences Discovery Research  Indianapolis IN 46268 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar V","family":"Garizi","sequence":"additional","affiliation":[{"name":"Dow AgroSciences Discovery Research  Indianapolis IN 46268 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1185383"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1237227"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2014.11.014"},{"key":"e_1_2_8_5_1","first-page":"28","volume-title":"Natural Product Chemistry for Drug Discovery","author":"Singh S","year":"2010"},{"key":"e_1_2_8_6_1","first-page":"3","volume-title":"Natural Product Chemistry for Drug Discovery","author":"Neuman DJ","year":"2010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins2081943"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/np300024u"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.3744"},{"key":"e_1_2_8_10_1","first-page":"311","volume-title":"Agrochemicals from Natural Products","author":"Godfrey CRA","year":"1995"},{"key":"e_1_2_8_11_1","first-page":"63","volume-title":"Agrochemicals from Natural Products","author":"Henrick CA","year":"1995"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1556160"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pestbp.2013.05.012"},{"key":"e_1_2_8_14_1","unstructured":"Insecticide Resistance Action Committee (IRAC) [Online]. 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