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These new challenges underscore the demand for novel, high\u2010quality starting points to accelerate the discovery of new agrochemicals that address market challenges. This article discusses the efforts to identify the optimum ranges of physicochemical properties of agrochemicals through analysis of modern commercial products. Specifically, we reviewed literature studies examining physicochemical property effects and analyzed the properties typical of successful fungicides, herbicides, and insecticides (chewing and sap\u2010feeding pests). From the analysis, a new set of physicochemical property guidelines for each discipline, as well as building block class, are proposed. These new guidelines should significantly aid in the discovery of next\u2010generation agrochemicals. \u00a9 2018 Society of Chemical Industry<\/jats:p>","DOI":"10.1002\/ps.5037","type":"journal-article","created":{"date-parts":[[2018,4,17]],"date-time":"2018-04-17T22:10:03Z","timestamp":1524003003000},"page":"1979-1991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":121,"title":["Physicochemical property guidelines for modern agrochemicals"],"prefix":"10.1002","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0886-3495","authenticated-orcid":false,"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"Crop Protection Discovery Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beth A","family":"Lorsbach","sequence":"additional","affiliation":[{"name":"Crop Protection Discovery Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Castetter","sequence":"additional","affiliation":[{"name":"Crop Protection Discovery Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William T","family":"Lambert","sequence":"additional","affiliation":[{"name":"Crop Protection Discovery Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Kister","sequence":"additional","affiliation":[{"name":"Crop Protection Discovery Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick X","family":"Wang","sequence":"additional","affiliation":[{"name":"Crop Protection Discovery Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla J R","family":"Klittich","sequence":"additional","affiliation":[{"name":"Crop Protection Discovery Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Roth","sequence":"additional","affiliation":[{"name":"Crop Protection Discovery Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C","family":"Sparks","sequence":"additional","affiliation":[{"name":"Crop Protection Discovery Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike R","family":"Loso","sequence":"additional","affiliation":[{"name":"Crop Protection Discovery Dow AgroSciences  Indianapolis IN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,6,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4457"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/bk-2015-1204.ch001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/bk-2015-1204.ch003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4190"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(96)00423-1"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1526-4998(200101)57:1<3::AID-PS269>3.0.CO;2-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/bk-2015-1204.ch002"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4336"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.2533\/000942903777678641"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/bk-2007-0948.ch002"},{"key":"e_1_2_6_12_1","unstructured":"BriggsGG DesborderP GenixP Are there limits to the physical properties of fungicides? 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